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. 1976 Jan;17(1):54–57. doi: 10.1136/gut.17.1.54

Effects of aspirin on gastric prostaglandin E (PGE) and acid output in normal subjects.

C Child, W Jubiz, J G Moore
PMCID: PMC1411058  PMID: 1269980

Abstract

Aspirin administration to normal subjects resulted in a reduction in gastric prostaglandin E (PGE) output. Both PGE concentration and gastric juice volume were decreased. Gastric acid output also decreased, although the difference was not statistically significant. An increased sensitivity of the PGE system to inhibition by aspirin at 11 p.m., midnight, and 1am was observed.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bennett A., Stamford I. F., Unger W. G. Prostaglandin E2 and gastric acid secretion in man. J Physiol. 1973 Mar;229(2):349–360. doi: 10.1113/jphysiol.1973.sp010142. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Classen M., Koch H., Bickhardt J., Topf G., Demling L. The effect of prostaglandin E 1 on the pentagastrin-stimulated gastric secretion in man. Digestion. 1971;4(6):333–344. doi: 10.1159/000197138. [DOI] [PubMed] [Google Scholar]
  3. Horton E. W., Main I. H., Thompson C. J., Wright P. M. Effect of orally administered prostaglandin E1 on gastric secretion and gastrointestinal motility in man. Gut. 1968 Dec;9(6):655–658. doi: 10.1136/gut.9.6.655. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Jubiz W., Frailey J., Child C., Bartholomew K. Physiologic role of prostaglandins of the E(PGE), F(PGF) and AB(PGAB) groups. Estimation by radioimmunoassay in unextracted human plasma. Prostaglandins. 1972 Dec;2(6):471–489. doi: 10.1016/s0090-6980(72)80034-0. [DOI] [PubMed] [Google Scholar]
  5. Pace-Asciak C. Prostaglandin synthetase activity in the rat stomach fundus. Activation by L-norepinephrine and related compounds. Biochim Biophys Acta. 1972 Sep 7;280(1):161–171. doi: 10.1016/0005-2760(72)90221-4. [DOI] [PubMed] [Google Scholar]
  6. Robert A., Nezamis J. E., Phillips J. P. Effect of prostaglandin E1 on gastric secretion and ulcer formation in the rat. Gastroenterology. 1968 Oct;55(4):481–487. [PubMed] [Google Scholar]
  7. Robert A., Stowe D. F., Nezamis J. E. Prevention of duodenal ulcers by administration of prostaglandin E 2 (PGE 2 ). Scand J Gastroenterol. 1971;6(4):303–305. doi: 10.3109/00365527109181124. [DOI] [PubMed] [Google Scholar]
  8. TRINDER P. Rapid determination of salicylate in biological fluids. Biochem J. 1954 Jun;57(2):301–303. doi: 10.1042/bj0570301. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Tonnesen M. G., Jubiz W., Moore J. G., Frailey J. Circadian variation of prostaglandin E(PGE) production in human gastric juice. Am J Dig Dis. 1974 Jul;19(7):644–648. doi: 10.1007/BF01073020. [DOI] [PubMed] [Google Scholar]
  10. Vane J. R. Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs. Nat New Biol. 1971 Jun 23;231(25):232–235. doi: 10.1038/newbio231232a0. [DOI] [PubMed] [Google Scholar]
  11. Wilson D. E. Prostaglandins: their actions on the gastrointestinal tract. Arch Intern Med. 1974 Jan;133(1):112–118. doi: 10.1001/archinte.133.1.112. [DOI] [PubMed] [Google Scholar]

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