Skip to main content
NCBI home page
Gut logoLink to Gut
. 1976 Feb;17(2):113–118. doi: 10.1136/gut.17.2.113

Nutrition in cryptogenic cirrhosis and chronic aggressive hepatitis.

A G Morgan, J Kelleher, B E Walker, M S Losowsky
PMCID: PMC1411074  PMID: 131055

Abstract

The nutritional status of 80 patients with non-alcoholic chronic liver disease was assessed by determination of various nutritional parameters in body fluids. With the exception of vitamin C there was a higher incidence (40%) of fat soluble vitamin deficiency (vitamins A, E, and carotene) than of the water soluble vitamins. Less than 10% of patients showed evidence of vitamin B12, nicotinic acid, thiamin, or riboflavin deficiency, and 17% had evidence of folic acid deficiency. The presence of deficiency was not related to age of the patient or fat absorption, and an inadequate dietary intake was not a major cause of deficiency. The incidence of nutritional deficiency is less frequent in non-alcoholic as compared with alcoholic liver disease.

Full text

PDF
113

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. ANDERSON B. B. INVESTIGATIONS INTO THE EUGLENA METHOD FOR THE ASSAY OF THE VITAMIN B12 IN SERUM. J Clin Pathol. 1964 Jan;17:14–26. doi: 10.1136/jcp.17.1.14. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. BAKER H., FRANK O., ZIFFER H., GOLDFARB S., LEEVY C. M., SOBOTKA H. EFFECT OF HEPATIC DISEASE ON LIVER B-COMPLEX VITAMIN TITERS. Am J Clin Nutr. 1964 Jan;14:1–6. doi: 10.1093/ajcn/14.1.1. [DOI] [PubMed] [Google Scholar]
  3. Brook M., Grimshaw J. J. Vitamin C concentration of plasma and leukocytes as related to smoking habit, age, and sex of humans. Am J Clin Nutr. 1968 Nov;21(11):1254–1258. doi: 10.1093/ajcn/21.11.1254. [DOI] [PubMed] [Google Scholar]
  4. Cherrick G. R., Baker H., Frank O., Leevy C. M. Observations on hepatic acidity for folate in Laennec's cirrhosis. J Lab Clin Med. 1965 Sep;66(3):446–451. [PubMed] [Google Scholar]
  5. DENSON K. W., BOWERS E. F. The determination of ascorbic acid in white blood cells. A comparison of W.B.C. ascorbic acid and phenolic acid excretion in elderly patients. Clin Sci. 1961 Oct;21:157–162. [PubMed] [Google Scholar]
  6. DITLEFSEN E. M. L., STØA K. F. Vitamin-A and carotenoid levels in blood serum with special reference to values observed in diseases of the liver. Scand J Clin Lab Invest. 1954;6(3):210–216. [PubMed] [Google Scholar]
  7. Eichner E. R., Hillman R. S. The evolution of anemia in alcoholic patients. Am J Med. 1971 Feb;50(2):218–232. doi: 10.1016/0002-9343(71)90151-3. [DOI] [PubMed] [Google Scholar]
  8. Fennelly J., Frank O., Baker H., Leevy C. M. Red blood cell-transketolase activity in malnourished alcoholics with cirrhosis. Am J Clin Nutr. 1967 Sep;20(9):946–949. doi: 10.1093/ajcn/20.9.946. [DOI] [PubMed] [Google Scholar]
  9. GABUZDA G. J., DAVIDSON C. S. Tryptophan and nicotinic acid metabolism in patients with cirrhosis of the liver. Am J Clin Nutr. 1962 Nov;11:502–508. doi: 10.1093/ajcn/11.5.502. [DOI] [PubMed] [Google Scholar]
  10. Giovanniello T. J., DiBenedetto G., Palmer D. W., Peters T., Jr Fully and semi-automated methods for the determination of serum iron and total iron-binding capacity. J Lab Clin Med. 1968 May;71(5):874–883. [PubMed] [Google Scholar]
  11. HERBERT V., ZALUSKY R., DAVIDSON C. S. Correlation of folate deficiency with alcoholism and associated macrocytosis, anemia, and liver disease. Ann Intern Med. 1963 Jun;58:977–988. doi: 10.7326/0003-4819-58-6-977. [DOI] [PubMed] [Google Scholar]
  12. Halsted C. H., Robles E. A., Mezey E. Decreased jejunal uptake of labeled folic acid ( 3 H-PGA) in alcoholic patients: roles of alcohol and nutrition. N Engl J Med. 1971 Sep 23;285(13):701–706. doi: 10.1056/NEJM197109232851301. [DOI] [PubMed] [Google Scholar]
  13. Halsted C. H., Robles E. A., Mezey E. Intestinal malabsorption in folate-deficient alcoholics. Gastroenterology. 1973 Apr;64(4):526–532. [PubMed] [Google Scholar]
  14. Hoffbrand A. V., Newcombe F. A., Mollin D. L. Method of assay of red cell folate activity and the value of the assay as a test for folate deficiency. J Clin Pathol. 1966 Jan;19(1):17–28. doi: 10.1136/jcp.19.1.17. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. JOSKE R. A. THE VITAMIN B12 CONTENT OF HUMAN LIVER TISSUE OBTAINED BY ASPIRATION BIOPSY. Gut. 1963 Sep;4:231–235. doi: 10.1136/gut.4.3.231. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Jacobs A., Greenman D., Owen E., Cavill I. Ascorbic acid status in iron-deficiency anaemia. J Clin Pathol. 1971 Nov;24(8):694–697. doi: 10.1136/jcp.24.8.694. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. KIMBER C., DELLER D. J., IBBOTSON R. N., LANDER H. THE MECHANISM OF ANAEMIA IN CHRONIC LIVER DISEASE. Q J Med. 1965 Jan;34:33–64. [PubMed] [Google Scholar]
  18. KLIPSTEIN F. A., LINDENBAUM J. FOLATE DEFICIENCY IN CHRONIC LIVER DISEASE. Blood. 1965 Apr;25:443–456. [PubMed] [Google Scholar]
  19. Konttinen A., Louhija A., Härtel G. Blood transketolase in assessment of thiamine deficiency in alcoholics. Ann Med Exp Biol Fenn. 1970;48(3):172–175. [PubMed] [Google Scholar]
  20. Leevy C. M., Tamburro C., Smith F. Alcoholism, drug addiction, and nutrition. Med Clin North Am. 1970 Nov;54(6):1567–1575. [PubMed] [Google Scholar]
  21. Leevy C. M., Thompson A., Baker H. Vitamins and liver injury. Am J Clin Nutr. 1970 Apr;23(4):493–499. doi: 10.1093/ajcn/23.4.493. [DOI] [PubMed] [Google Scholar]
  22. Linscheer W. G. Malabsorption in cirrhosis. Am J Clin Nutr. 1970 Apr;23(4):488–492. doi: 10.1093/ajcn/23.4.488. [DOI] [PubMed] [Google Scholar]
  23. Lipschitz D. A., Cook J. D., Finch C. A. A clinical evaluation of serum ferritin as an index of iron stores. N Engl J Med. 1974 May 30;290(22):1213–1216. doi: 10.1056/NEJM197405302902201. [DOI] [PubMed] [Google Scholar]
  24. Losowsky M. S., Walker B. E. Liver disease and malabsorption. Gastroenterology. 1969 Mar;56(3):589–600. [PubMed] [Google Scholar]
  25. Lundvall O., Weinfeld A., Lundin P. Iron stores in alcohol abusers. I. Liver iron. Acta Med Scand. 1969 Apr;185(4):259–269. doi: 10.1111/j.0954-6820.1969.tb07332.x. [DOI] [PubMed] [Google Scholar]
  26. PELLETIER O., CAMPBELL J. A. A rapid method for the determination of N'-methylnicotinamide in urine. Anal Biochem. 1962 Jan;3:60–67. doi: 10.1016/0003-2697(62)90044-1. [DOI] [PubMed] [Google Scholar]
  27. Powell W. J., Jr, Klatskin G. Duration of survival in patients with Laennec's cirrhosis. Influence of alcohol withdrawal, and possible effects of recent changes in general management of the disease. Am J Med. 1968 Mar;44(3):406–420. doi: 10.1016/0002-9343(68)90111-3. [DOI] [PubMed] [Google Scholar]
  28. SUMMERSKILL W. H., MOERTEL C. G. Malabsorption syndrome associated with anicteric liver disease. Gastroenterology. 1962 Apr;42:380–392. [PubMed] [Google Scholar]
  29. Smith F. R., Goodman D. S. The effects of diseases of the liver, thyroid, and kidneys on the transport of vitamin A in human plasma. J Clin Invest. 1971 Nov;50(11):2426–2436. doi: 10.1172/JCI106741. [DOI] [PMC free article] [PubMed] [Google Scholar]
  30. Stone W. D., Islam N. R., Paton A. The natural history of cirrhosis. Experience with an unselected group of patients. Q J Med. 1968 Jan;37(145):119–132. [PubMed] [Google Scholar]
  31. Sun D. C., Albacete R. A., Chen J. K. Malabsorption studies in cirrhosis of the liver. Arch Intern Med. 1967 Jun;119(6):567–572. [PubMed] [Google Scholar]
  32. VAN GOIDSENHOVEN G. E., HENKE W. J., VACCA J. B., KNIGHT W. A., Jr Pancreatic fnction in cirrhosis of the liver. Am J Dig Dis. 1963 Feb;8:160–173. [PubMed] [Google Scholar]
  33. WATERS A. H., MOLLIN D. L. Studies on the folic acid activity of human serum. J Clin Pathol. 1961 Jul;14:335–344. doi: 10.1136/jcp.14.4.335. [DOI] [PMC free article] [PubMed] [Google Scholar]
  34. WHITE D. P., BONE F. C., RUFFIN J. M., TAYLOR H. Further observations on the value of plasma Vitamin A determination in the differential diagnosis of jaundice. Gastroenterology. 1950 Apr;14(4):541–548. [PubMed] [Google Scholar]
  35. Williams C. N., Sidorov J. J. Steatorrhea in patients with liver disease. Can Med Assoc J. 1971 Dec 4;105(11):1143–passim. [PMC free article] [PubMed] [Google Scholar]
  36. Williams I. R., Girdwood R. H. The folate status of alcoholics. Scott Med J. 1970 Aug;15(8):285–288. doi: 10.1177/003693307001500803. [DOI] [PubMed] [Google Scholar]

Articles from Gut are provided here courtesy of BMJ Publishing Group

RESOURCES