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. 1976 Jul;17(7):489–491. doi: 10.1136/gut.17.7.489

Factor VII levels as a guide to prognosis in fulminant hepatic failure.

B G Gazzard, J M Henderson, R Williams
PMCID: PMC1411167  PMID: 964680

Abstract

Levels of clotting factors II, V, and VII were measured on admission and then daily in 12 patients with grade IV hepatic coma due to fulminant hepatic failure. Factor VII levels obtained within 36 hours of the development of grade IV coma were not of value in predicting which patients would subsequently recover consciousness. Four of the latter group had levels below 9% at this time while the levels in three of the seven fatal cases were higher. Serial determinations were of more value and levels rose rapidly in those patients who ultimately made a complete recovery.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BIGGS R., DOUGLAS A. S. The thromboplastin generation test. J Clin Pathol. 1953 Feb;6(1):23–29. doi: 10.1136/jcp.6.1.23. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. BRECHER G., CRONKITE E. P. Morphology and enumeration of human blood platelets. J Appl Physiol. 1950 Dec;3(6):365–377. doi: 10.1152/jappl.1950.3.6.365. [DOI] [PubMed] [Google Scholar]
  3. Dymock I. W., Tucker J. S., Woolf I. L., Poller L., Thomson J. M. Coagulation studies as a prognostic index in acute liver failure. Br J Haematol. 1975 Mar;29(3):385–395. doi: 10.1111/j.1365-2141.1975.tb01836.x. [DOI] [PubMed] [Google Scholar]
  4. Gazzard B. G., Weston M. J., Murray-Lyon I. M., Flax H., Record C. O., Williams R., Portmann B., Langley P. G., Dunlop E. H., Mellon P. J. Charcoal haemoperfusion in the treatment of fulminant hepatic failure. Lancet. 1974 Jun 29;1(7870):1301–1307. doi: 10.1016/s0140-6736(74)90678-3. [DOI] [PubMed] [Google Scholar]
  5. INGRAM G. I. A suggested schedule for the rapid investigation of acute haemostatic failure. J Clin Pathol. 1961 Jul;14:356–360. doi: 10.1136/jcp.14.4.356. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Karvountzis G. G., Redeker A. G. Relation of alpha-fetoprotein in acute hepatitis to severity and prognosis. Ann Intern Med. 1974 Feb;80(2):156–160. doi: 10.7326/0003-4819-80-2-156. [DOI] [PubMed] [Google Scholar]
  7. Merskey C., Lalezari P., Johnson A. J. A rapid, simple, sensitive method for measuring fibrinolytic split products in human serum. Proc Soc Exp Biol Med. 1969 Jul;131(3):871–875. doi: 10.3181/00379727-131-33998. [DOI] [PubMed] [Google Scholar]
  8. Rake M. O., Flute P. T., Shilkin K. B., Lewis M. L., Winch J., Williams R. Early and intensive therapy of intravascular coagulation in acute liver failure. Lancet. 1971 Dec 4;2(7736):1215–1218. doi: 10.1016/s0140-6736(71)90540-x. [DOI] [PubMed] [Google Scholar]
  9. Roberts H. R., Cederbaum A. I. The liver and blood coagulation: physiology and pathology. Gastroenterology. 1972 Aug;63(2):297–320. [PubMed] [Google Scholar]
  10. Trey C., Davidson C. S. The management of fulminant hepatic failure. Prog Liver Dis. 1970;3:282–298. [PubMed] [Google Scholar]
  11. Weibel E. R., Kistler G. S., Scherle W. F. Practical stereological methods for morphometric cytology. J Cell Biol. 1966 Jul;30(1):23–38. doi: 10.1083/jcb.30.1.23. [DOI] [PMC free article] [PubMed] [Google Scholar]

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