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. 1976 Dec;17(12):965–970. doi: 10.1136/gut.17.12.965

Idiopathic bile acid catharsis.

E H Thaysen, L Pedersen
PMCID: PMC1411224  PMID: 1017717

Abstract

In the course of extensive routine screening for bile acid malabsorption a few patients were detected in whom chronic diarrhoea was apparently induced by excess bile acid loss which was neither associated with demonstrable conventional ileopathy nor with any other disorder allied to diarrhoea. In three patients subjected to scrutiny the results obtained were in harmony with a concept of idiopathic bile acid catharsis. Ingestion of cholestyramine was followed by immediate relief, but the diarrhoea recurred whenever this treatment was withdrawn. It it suggested that idiopathic bile acid catharsis should be suspected in patients with unexplained chronic diarrhoea and especially in those with a diagnosis of irritable colon with diarrhoea.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Fromm H., Hofmann A. F. Breath test for altered bile-acid metabolism. Lancet. 1971 Sep 18;2(7725):621–625. doi: 10.1016/s0140-6736(71)80068-5. [DOI] [PubMed] [Google Scholar]
  2. Meihoff W. E., Kern F., Jr Bile salt malabsorption in regional ileitis, ileal resection and mannitol-induced diarrhea. J Clin Invest. 1968 Feb;47(2):261–267. doi: 10.1172/JCI105722. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Pedersen L., Arnfred T., Thaysen E. H. Rapid screening of increased bile acid deconjugation and bile acid malabsorption by means of the glycine-l-(14C) cholylglycine assay. Scand J Gastroenterol. 1973;8(7):665–672. [PubMed] [Google Scholar]
  4. Small D. M., Dowling R. H., Redinger R. N. The enterohepatic circulation of bile salts. Arch Intern Med. 1972 Oct;130(4):552–573. [PubMed] [Google Scholar]
  5. Thaysen E. H., Pedersen L. Diarrhoea associated with idiopathic bile acid malabsorption. Fact or fantasy? Dan Med Bull. 1973 Dec;20(6):174–177. [PubMed] [Google Scholar]

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