Skip to main content
PMC home page
Gut logoLink to Gut
. 1977 Jan;18(1):48–52. doi: 10.1136/gut.18.1.48

Reinvestigation of lactose intolerant children: lack of correlation between continuing lactose intolerance and small intestinal morphology, disaccharidase activity, and lactose tolerance tests.

M Harrison, J A Walker-Smith
PMCID: PMC1411261  PMID: 838402

Abstract

Thirty children on a lactose-free diet aged from 2-38 months who had previously been diagnosed as having secondary lactose intolerance were reinvestigated on 32 occasions by an oral lactose tolerance test, small intestinal biopsy, and measurement of disaccharidase activity in order to detect the presence of continuing lactose intolerance before reintroduction of milk. No correlation was found between continuing lactose intolerance, as diagnosed by the development of watery stools containing excess reducing substances after an oral load of lactose, and maximum blood glucose rise during a lactose tolerance test, lactase levels, and small intestinal morphology.

Full text

PDF
48

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. AURICCHIO S., RUBINO A., PRADER A., REY J., JOS J., FREZAL J., DAVIDSON M. INTESTINAL GLYCOSIDASE ACTIVITIES IN CONGENITAL MALABSORPTION OF DISACCHARIDES. J Pediatr. 1965 Mar;66:555–564. doi: 10.1016/s0022-3476(65)80120-2. [DOI] [PubMed] [Google Scholar]
  2. BURGESS E. A., LEVIN B., MAHALANABIS D., TONGE R. E. HEREDITARY SUCROSE INTOLERANCE: LEVELS OF SUCRASE ACTIVITY IN JEJUNAL MUCOSA. Arch Dis Child. 1964 Oct;39:431–443. doi: 10.1136/adc.39.207.431. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Barnes G. L., Townley R. R. Duodenal mucosal damage in 31 infants with gastroenteritis. Arch Dis Child. 1973 May;48(5):343–349. doi: 10.1136/adc.48.5.343. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Harrison M., Kilby A., Walker-Smith J. A., France N. E., Wood C. B. Cows' milk protein intolerance: a possible association with gastroenteritis, lactose intolerance, and IgA deficiency. Br Med J. 1976 Jun 19;1(6024):1501–1504. doi: 10.1136/bmj.1.6024.1501. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Holdsworth C. D. The gut and oral glucose tolerance. Gut. 1969 Jun;10(6):422–427. doi: 10.1136/gut.10.6.422. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. KERRY K. R., ANDERSON C. M. A WARD TEST FOR SUGAR IN FAECES. Lancet. 1964 May 2;1(7340):981–981. doi: 10.1016/s0140-6736(64)91777-5. [DOI] [PubMed] [Google Scholar]
  7. Kilby A. Paediatric small intestinal biopsy capsule with two ports. Gut. 1976 Feb;17(2):158–159. doi: 10.1136/gut.17.2.158. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Krasilnikoff P. A., Gudman-Hoyer E., Moltke H. H. Diagnostic value of disaccharide tolerance tests in children. Acta Paediatr Scand. 1975 Sep;64(5):693–698. doi: 10.1111/j.1651-2227.1975.tb03906.x. [DOI] [PubMed] [Google Scholar]
  9. Newcomer A. D., McGill D. B. Lactose tolerance tests in adults with normal lactase activity. Gastroenterology. 1966 Mar;50(3):340–346. [PubMed] [Google Scholar]
  10. Soeparto P., Stobo E. A., Walker-Smith J. A. Role of chemical examination of the stool in diagnosis of sugar malabsorption in children. Arch Dis Child. 1972 Feb;47(251):56–61. doi: 10.1136/adc.47.251.56. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Townley R. R. Disaccharidase deficiency in infancy and childhood. Pediatrics. 1966 Jul;38(1):127–141. [PubMed] [Google Scholar]
  12. Walker-Smith J. A. Uniformity of dissecting microscope appearances in proximal small intestine. Gut. 1972 Jan;13(1):17–20. doi: 10.1136/gut.13.1.17. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from Gut are provided here courtesy of BMJ Publishing Group

RESOURCES