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. 1977 Jan;18(1):16–18. doi: 10.1136/gut.18.1.16

Amylase creatinine clearance ratio after biliary surgery.

L A Donaldson, W McIntosh, S N Joffe
PMCID: PMC1411264  PMID: 402305

Abstract

The amylase creatinine clearance ratio (ACCR) is considered to be a more sensitive index of acute pancreatitis than the serum amylase level. Serial ACCR estimations were undertaken in 25 patients undergoing an elective cholecystectomy. Using accepted criteria, 28% of these patients developed, in the postoperative period, biochemical evidence of pancreatic gland damage, although the serum amylase level remained normal. This raised ACCR was particularly noted in patients who had undergone an exploration of the common bile duct. The ACCR would appear to be a more sensitive index of pancreatic gland disruption secondary to biliary surgery than the serum amylase level.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bardenheier J. A., Kaminski D. L., Willman V. L. Pancreatitis after biliary tract surgery. Am J Surg. 1968 Nov;116(5):773–776. doi: 10.1016/0002-9610(68)90366-8. [DOI] [PubMed] [Google Scholar]
  2. Ceska M., Birath K., Brown B. A new and rapid method for the clinical determination of alpha-amylase activities in human serum and urine. Optimal conditions. Clin Chim Acta. 1969 Dec;26(3):437–444. doi: 10.1016/0009-8981(69)90071-0. [DOI] [PubMed] [Google Scholar]
  3. Dreiling D. A., Leichtling J. J., Janowitz H. D. The amylase-creatinine clearance ratio. Diagnostic parameter or physiologic phenomenon? Am J Gastroenterol. 1974 Apr;61(4):290–296. [PubMed] [Google Scholar]
  4. Imrie C. W. Observations on acute pancreatitis. Br J Surg. 1974 Jul;61(7):539–544. doi: 10.1002/bjs.1800610710. [DOI] [PubMed] [Google Scholar]
  5. Imrie C. W., Whyte A. S. A prospective study of acute pancreatitis. Br J Surg. 1975 Jun;62(6):490–494. doi: 10.1002/bjs.1800620615. [DOI] [PubMed] [Google Scholar]
  6. Keighley M. R., Johnson A. G., Stevens A. E. Raised serum amylase after upper abdominal operation. Br J Surg. 1969 Jun;56(6):424–427. doi: 10.1002/bjs.1800560606. [DOI] [PubMed] [Google Scholar]
  7. Lesser P. B., Warshaw A. L. Differentiation of pancreatitis from common bile duct obstruction with hyperamylasemia. Gastroenterology. 1975 Apr;68(4 Pt 1):636–641. [PubMed] [Google Scholar]
  8. Levine R. I., Glauser F. L., Berk J. E. Enhancement of the amylase-creatinine clearance ratio in disorders other than acute pancreatitis. N Engl J Med. 1975 Feb 13;292(7):329–332. doi: 10.1056/NEJM197502132920702. [DOI] [PubMed] [Google Scholar]
  9. Levitt M. D., Rapoport M., Cooperband S. R. The renal clearance of amylase in renal insufficiency, acute pancreatitis, and macroamylasemia. Ann Intern Med. 1969 Nov;71(5):919–925. doi: 10.7326/0003-4819-71-5-919. [DOI] [PubMed] [Google Scholar]
  10. Miller S. F., Whitaker J. R., Jr, Snyder R. D. Incidence of elevated serum amylase levels and pancreatitis after upper abdominal surgery. Am J Surg. 1973 May;125(5):535–537. doi: 10.1016/0002-9610(73)90132-3. [DOI] [PubMed] [Google Scholar]
  11. SINGH L. M., OKUKUBO F., JAMES P. M., Jr, SALMON J., HOWARD J. M. FURTHER STUDIES ON POSTOPERATIVE PANCREATITIS. Arch Surg. 1965 Jan;90:43–49. doi: 10.1001/archsurg.1965.01320070045009. [DOI] [PubMed] [Google Scholar]
  12. Warshaw A. L., Fuller A. F., Jr Specificity of increased renal clearance of amylase in diagnosis of acute pancreatitis. N Engl J Med. 1975 Feb 13;292(7):325–328. doi: 10.1056/NEJM197502132920701. [DOI] [PubMed] [Google Scholar]

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