Skip to main content
NCBI home page
Gut logoLink to Gut
. 1970 Feb;11(2):153–157. doi: 10.1136/gut.11.2.153

Maximal acid response of Pavlov pouches to food and histamine

A Marvin Brooks, Morton I Grossman
PMCID: PMC1411343  PMID: 5441885

Abstract

Secretion of gastric acid in response to histamine, insulin, and a meal of liver, with and without 5% bone dust, was studied in three dogs with Pavlov pouches and gastric fistulas. The ratios of insulin-induced to histamine-induced secretion were the same in pouch and main stomach indicating that their innervation was equivalent. Meals of a liver and bone dust mixture in amounts of 11 to 44 g/kg resulted in Pavlov pouch acid outputs that were 34 to 56% higher than the maximal response to histamine (p < 0·05 to < 0·001). Liver without bone dust also produced higher acid outputs than histamine. These results indicate that combinations of endogenously generated stimuli can produce a potentiated gastric response which exceeds that produced by histamine alone.

Full text

PDF
153

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. CODE C. F., WATKINSON G. Importance of vagal innervation in the regulatory effect of acid in the duodenum on gastric secretion of acid. J Physiol. 1955 Oct 28;130(1):233–252. doi: 10.1113/jphysiol.1955.sp005406. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Checketts R. G., Gillespie I. E., Kay A. W. Insulin potentiation of the augmented histamine response. Gut. 1968 Dec;9(6):683–687. doi: 10.1136/gut.9.6.683. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. GILLESPIE I. E., GROSSMAN M. I. POTENTIATION BETWEEN URECHOLINE AND GASTRIN EXTRACT AND BETWEEN URECHOLINE AND HISTAMINE IN THE STIMULATIONS OF HEIDENHAIN POUCHES. Gut. 1964 Feb;5:71–76. doi: 10.1136/gut.5.1.71. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. GREGORY R. A. Gastric secretory responses after portal venous ligation. J Physiol. 1958 Nov 10;144(1):123–137. doi: 10.1113/jphysiol.1958.sp006090. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Johnson L. R., Grossman M. I. Potentiation of gastric acid response in the dog. Gastroenterology. 1969 Apr;56(4):687–692. [PubMed] [Google Scholar]
  6. Konturek S. J., Oleksy J. Potentiation between pentapeptide (ICI 50123) and histamine in the stimulation of gastric secretion in man. Gastroenterology. 1967 Dec;53(6):912–917. [PubMed] [Google Scholar]
  7. Makhlouf G. M., McManus J. P., Knill J. R. Quantitative aspects of synergism and inhibition of gastric acid secretion. Gastroenterology. 1968 Apr;54(4):532–537. [PubMed] [Google Scholar]
  8. OBRINK K. J. Bonedust-meat mixture as a test meal for continuous gastric secretion. Acta Physiol Scand. 1954;30(2-3):275–281. doi: 10.1111/j.1748-1716.1954.tb01095.x. [DOI] [PubMed] [Google Scholar]
  9. PASSARO E. P., Jr, GILLESPIE I. E., GROSSMAN M. I. POTENTIATION BETWEEN GASTRIN AND HISTAMINE IN STIMULATION OF GASTRIC SECRETION. Proc Soc Exp Biol Med. 1963 Oct;114:50–52. doi: 10.3181/00379727-114-28582. [DOI] [PubMed] [Google Scholar]
  10. Rune S. J. Comparison of the rates of gastric acid secretion in man after ingestion of food and after maximal stimulation with histamine. Gut. 1966 Aug;7(4):344–350. doi: 10.1136/gut.7.4.344. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Thomas W. R., Forrest A. P. Acid secretion from canine separated fundic pouches. Gastroenterology. 1967 Feb;52(2):192–197. [PubMed] [Google Scholar]

Articles from Gut are provided here courtesy of BMJ Publishing Group

RESOURCES