Abstract
Fifty-six surgical specimens with various ulcerative intestinal disorders were microscopically investigated for evidence of gastric gland metaplasia. Thiry-one specimens (55-4%) showed pyloric gland metaplasia. Among the 31 patients with pyloric gland metaplasia, five showed true gastric metaplasia, consisting of parietal cells, chief cells, and mucous neck cells. The percentage of true gastric metaplasia among pyloric gland metaplasia was as high as 16%, an overall frequency of 9% among various ulcerative intestinal disorders. The mechanism of pyloric gland metaplasia and true gastric metaplasia is not understood, but may occur secondary to submucosal response to ulcer healing and subsequent alteration of the intraluminal condition in the intestine.
Full text
PDF
Images in this article
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- ANTONIUS J. I., GUMP F. E., LATTES R., LEPORE M. A study of certain microscopic features in regional enteritis, and their possible prognostic significance. Gastroenterology. 1960 Jun;38:889–905. [PubMed] [Google Scholar]
- Duffy G., Enriquez A. A., Watson W. C. Duplication of the ileum with heterotopic gastric mucosa pseudomyxoma peritonei and nonrotation of the midgut. Gastroenterology. 1974 Aug;67(2):341–346. [PubMed] [Google Scholar]
- Hoedemaeker P. J. Heterotopic gastric mucosa in the duodenum. Digestion. 1970;3(3):165–173. doi: 10.1159/000197027. [DOI] [PubMed] [Google Scholar]
- JAMES A. H. GASTRIC EPITHELIUM IN THE DUODENUM. Gut. 1964 Aug;5:285–294. doi: 10.1136/gut.5.4.285. [DOI] [PMC free article] [PubMed] [Google Scholar]
- LIBER A. F. Aberrant pyloric glands in regional ileitis. AMA Arch Pathol. 1951 Feb;51(2):205–212. [PubMed] [Google Scholar]
- Lee S. M., Mosenthal W. T., Weismann R. E. Tumorous heterotopic gastric mucosa in the small intestine. Arch Surg. 1970 May;100(5):619–622. doi: 10.1001/archsurg.1970.01340230085022. [DOI] [PubMed] [Google Scholar]
- Nawaz K., Graham D. Y., Fechner R. E., Eiband J. M. Gastric heterotopia in the ileum with ulceration and chronic bleeding. Gastroenterology. 1974 Jan;66(1):113–117. [PubMed] [Google Scholar]
- RIPSTEIN C. B. Duplication of the small intestine. Am J Surg. 1949 Dec;78(6):847-52, illust. doi: 10.1016/0002-9610(49)90230-5. [DOI] [PubMed] [Google Scholar]
- STOCKMAN J. M., YOUNG V. T., JENKINS A. L. Duplication of the rectum containing gastric mucosa. JAMA. 1960 Jul 16;173:1223–1225. doi: 10.1001/jama.1960.73020290004010a. [DOI] [PubMed] [Google Scholar]
- Trier J. S., Moxey P. C., Fordtran J. S., MacDermott R. P. Ectopic gastric mucosa in celiac sprue. Gastroenterology. 1973 Nov;65(5):712–727. [PubMed] [Google Scholar]