Abstract
Two independent lines of chemically-induced colonic carcinoma, serially graftable in syngeneic rats, have been used to investigate the effects of immunoprophylaxis and immunotherapy. Rats were immunised by various procedures, including BCG, irradiated tumour grafts, and cancer cells treated by mitomycin and neuraminidase. A partial inhibition of tumour growth was observed in one of the four protocols. On the other hand, a significant enhancement of tumour growth was obtained in two other experiments.
Full text
PDF



Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Baldwin R. W., Barker C. R. Tumour-specific antigenicity of aminoazo-dye-induced rat hepatomas. Int J Cancer. 1967 Jul 15;2(4):355–364. doi: 10.1002/ijc.2910020410. [DOI] [PubMed] [Google Scholar]
- Baldwin R. W., Embleton M. J., Jones J. S., Langman M. J. Cell-mediated and humoral immune reactions to human tumours. Int J Cancer. 1973 Jul 15;12(1):73–83. doi: 10.1002/ijc.2910120108. [DOI] [PubMed] [Google Scholar]
- Baldwin R. W., Pimm M. V. BCG immunotherapy of rat tumors of defined immunogenicity. Natl Cancer Inst Monogr. 1973 Dec;39:11–19. [PubMed] [Google Scholar]
- Bartlett G. L., Zbar B. Tumor-specific vaccine containing Mycobacterium bovis and tumor cells: safety and efficacy. J Natl Cancer Inst. 1972 Jun;48(6):1709–1726. [PubMed] [Google Scholar]
- Falk R. E., MacGregor A. B., Landi S., Ambus U., Langer B. Immunostimulation with intraperitoneally administered bacille Calmette Guérin for advanced malignant tumors of the gastrointestinal tract. Surg Gynecol Obstet. 1976 Mar;142(3):363–368. [PubMed] [Google Scholar]
- Hellström I., Hellström K. E., Shepard T. H. Cell-mediated immunity against antigens common to human colonic carcinomas and fetal gut epithelium. Int J Cancer. 1970 Nov 15;6(3):346–351. doi: 10.1002/ijc.2910060304. [DOI] [PubMed] [Google Scholar]
- Hollinshead A., Glew D., Bunnag B., Gold P., Herberman R. Skin-reactive soluble antigen from intestinal cancer-cell-membranes and relationship to carcinoembryonic antigens. Lancet. 1970 Jun 6;1(7658):1191–1195. doi: 10.1016/s0140-6736(70)91784-8. [DOI] [PubMed] [Google Scholar]
- Kreider J. W., Bartlett G. L., Purnell D. M. Suitability of rat mammary adenocarcinoma 13762 as a model for BCG immunotherapy. J Natl Cancer Inst. 1976 Apr;56(4):797–802. doi: 10.1093/jnci/56.4.797. [DOI] [PubMed] [Google Scholar]
- Martin F., Knobel S., Martin M., Bordes M. A carcinofetal antigen located on the membrane of cells from rat intestinal carcinoma in culture. Cancer Res. 1975 Feb;35(2):333–336. [PubMed] [Google Scholar]
- Martin F., Martin M., Lagneau A., Bordes M., Knobel S. Circulating antibodies in rats bearing grafted colon carcinoma. Cancer Res. 1976 Sep;36(9 PT1):3039–3042. [PubMed] [Google Scholar]
- Martin M. S., Martin F., Michiels R., Bastien H., Justrabo E., Bordes M., Viry B. An experimental model for cancer of the colon and rectum. Intestinal carcinoma induced in the rat 1,2-dimethylhydrazine. Digestion. 1973;8(1):22–34. doi: 10.1159/000197298. [DOI] [PubMed] [Google Scholar]
- Mavligit G. M., Gutterman J. U., Burgess M. A., Khankhanian N., Seibert G. B., Speer J. F., Jubert A. V., Martin R. C., McBride C. M., Copeland E. M. Prolongation of postoperative disease-free interval and survival in human colorectal cancer by B.C.G. or B.C.G. plus 5-fluorouracil. Lancet. 1976 Apr 24;1(7965):871–876. doi: 10.1016/s0140-6736(76)92093-6. [DOI] [PubMed] [Google Scholar]
- Moertel C. G., Ritts R. E., Jr, Schutt A. J., Hahn R. G. Clinical studies of methanol extraction residue fraction of Bacillus Calmette-Guérin as an immunostimulant in patients with advanced cancer. Cancer Res. 1975 Nov;35(11 Pt 1):3075–3083. [PubMed] [Google Scholar]
- Piessens W. F., Lachapelle F. L., Legros N., Heuson J. C. Facilitation of rat mammary tumour growth by BCG. Nature. 1970 Dec 19;228(5277):1210–1211. doi: 10.1038/2281210a0. [DOI] [PubMed] [Google Scholar]
- Rogers A. E., Gildin J. Effect of BCG on dimethylhydrazine induction of colon tumors in rats. J Natl Cancer Inst. 1975 Aug;55(2):385–391. [PubMed] [Google Scholar]
- Simmons R. L., Rios A. Comparative and combined effect of BCG and neuraminidase in experimental immunotherapy. Natl Cancer Inst Monogr. 1973 Dec;39:57–68. [PubMed] [Google Scholar]
- Sparks F. C., Breeding J. H. Tumor regression and enhancement resulting from immunotherapy with Bacillus Calmette-Guérin and neuraminidase. Cancer Res. 1974 Dec;34(12):3262–3269. [PubMed] [Google Scholar]
- Steele G., Jr, Sjögren H. O. Cross-reacting tumor-associated antigen (s) among chemically induced rat colon carcinomas. Cancer Res. 1974 Aug;34(8):1801–1807. [PubMed] [Google Scholar]
- Steele G., Jr, Sjögren H. O., Rosengren J. E., Lindström C., Larsson A., Leandoer L. Sequential studies of serum blocking activity in rats bearing chemically induced primary bowel tumors. J Natl Cancer Inst. 1975 Apr;54(4):959–967. [PubMed] [Google Scholar]
