Abstract
In two series of conscious healthy dogs, a study of duodenal electric activity was made to locate the pacemaker or site of the greatest intrinsic frequency of the pacesetter potential. In three dogs, an annular myotomy of the duodenum about 1 cm proximal (orad) to the biliary ampulla caused a reduction in the frequency of the pacesetter potential distal (caudad) to the conduction block and demonstrated that the pacemaker was not in the region of the ampulla, as had been suggested previously. Annular myotomy of the duodenum at increasing intervals distal to the pylorus in a second series of eight dogs showed that the pacemaker was present in the proximal 5 to 6 mm of duodenum. The greater frequency of the pacemaker was found to maintain constant distal conduction of the pacesetter potential. Distal conduction of the pacesetter potential was shown on occasion to be associated with the distal propagation of action potentials along the duodenum.
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- ARMSTRONG H. I., MILTON G. W., SMITH A. W. Electropotential changes of the small intestine. J Physiol. 1956 Jan 27;131(1):147–153. doi: 10.1113/jphysiol.1956.sp005451. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Bortoff A. Electrical transmission of slow waves from longitudinal to circular intestinal muscle. Am J Physiol. 1965 Dec;209(6):1254–1260. doi: 10.1152/ajplegacy.1965.209.6.1254. [DOI] [PubMed] [Google Scholar]
- Bunker C. E., Johnson L. P., Nelsen T. S. Chronic in situ studies of the electrical activity of the small intestine. Arch Surg. 1967 Aug;95(2):259–268. doi: 10.1001/archsurg.1967.01330140097023. [DOI] [PubMed] [Google Scholar]
- DANIEL E. E., BOGOCH A. Mechanical and electrical activity of ileal segments isolated for uretero-ileal anastomosis. Can Med Assoc J. 1959 Jan 15;80(2):95–102. [PMC free article] [PubMed] [Google Scholar]
- DANIEL E. E., CARLOW D. R., WACHTER B. T., SUTHERLAND W. H., BOGOCH A. Electrical activity of the small intestine. Gastroenterology. 1959 Sep;37:268–281. [PubMed] [Google Scholar]
- DANIEL E. E., HONOUR A. J., BOGOCH A. Electrical activity of the longitudinal muscle of dog small intestine studied in vivo using microelectrodes. Am J Physiol. 1960 Jan;198:113–118. doi: 10.1152/ajplegacy.1960.198.1.113. [DOI] [PubMed] [Google Scholar]
- Diamant N. E., Bortoff A. Effects of transection on the intestinal slow-wave frequency gradient. Am J Physiol. 1969 Apr;216(4):734–743. doi: 10.1152/ajplegacy.1969.216.4.734. [DOI] [PubMed] [Google Scholar]
- Diamant N. E., Bortoff A. Nature of the intestinal slow-wave frequency gradient. Am J Physiol. 1969 Feb;216(2):301–307. doi: 10.1152/ajplegacy.1969.216.2.301. [DOI] [PubMed] [Google Scholar]
- Douglas D. M. The activity of the duodenum. J Physiol. 1948 Sep 30;107(4):472–478. doi: 10.1113/jphysiol.1948.sp004292. [DOI] [PMC free article] [PubMed] [Google Scholar]
- HASSELBRACK R., THOMAS J. E. Control of intestinal rhythmic contractions by a duodenal pacemaker. Am J Physiol. 1961 Nov;201:955–960. doi: 10.1152/ajplegacy.1961.201.5.955. [DOI] [PubMed] [Google Scholar]
- Kobayashi M., Nagai T., Prosser C. L. Electrical interaction between muscle layers of cat intestine. Am J Physiol. 1966 Dec;211(6):1281–1291. doi: 10.1152/ajplegacy.1966.211.6.1281. [DOI] [PubMed] [Google Scholar]
- MILTON G. W., SMITH A. W. The pacemaking area of the duodenum. J Physiol. 1956 Apr 27;132(1):100–114. doi: 10.1113/jphysiol.1956.sp005505. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Nelsen T. S., Becker J. C. Simulation of the electrical and mechanical gradient of the small intestine. Am J Physiol. 1968 Apr;214(4):749–757. doi: 10.1152/ajplegacy.1968.214.4.749. [DOI] [PubMed] [Google Scholar]