Abstract
In view of data suggesting that deficiency of gamma glutamyl transferase (GGT) may be the primary abnormality in the small-intestinal mucosa of patients with coeliac disease, this enzyme was measured in mucosal biopsies from coeliac patients at different stages of treatment. Activity was only slightly reduced in only one of nine well-treated patients, suggesting that deficiency of this enzyme has no primary role in the aetiology of coeliac disease.
Full text
PDFSelected References
These references are in PubMed. This may not be the complete list of references from this article.
- Berg N. O., Dahlqvist A., Lindberg T., Nordén A. Intestinal dipeptidases and disaccharidases in celiac disease in adults. Gastroenterology. 1970 Oct;59(4):575–582. [PubMed] [Google Scholar]
- Curthoys N. P., Shapiro R. gamma-Glutamyltranspeptidase in intestinal brush border membranes. FEBS Lett. 1975 Oct 15;58(1):230–233. doi: 10.1016/0014-5793(75)80266-3. [DOI] [PubMed] [Google Scholar]
- DAHLQVIST A. METHOD FOR ASSAY OF INTESTINAL DISACCHARIDASES. Anal Biochem. 1964 Jan;7:18–25. doi: 10.1016/0003-2697(64)90115-0. [DOI] [PubMed] [Google Scholar]
- Greenberg E., Wollaeger E. E., Fleisher G. A., Engstrom G. W. Demonstration of gamma-glutamyl transpeptidase activity in human jejunal mucosa. Clin Chim Acta. 1967 Apr;16(1):79–89. doi: 10.1016/0009-8981(67)90272-0. [DOI] [PubMed] [Google Scholar]
- Holmes J. T., Klein M. S., Winawer S. J., Fortner J. G. Morphological studies of rejection in canine jejunal allographs. Gastroenterology. 1971 Nov;61(5):693–706. [PubMed] [Google Scholar]
- LOWRY O. H., ROSEBROUGH N. J., FARR A. L., RANDALL R. J. Protein measurement with the Folin phenol reagent. J Biol Chem. 1951 Nov;193(1):265–275. [PubMed] [Google Scholar]
- Lindberg T., Nordén A., Josefsson L. Intestinal dipeptidases. Dipeptidase activities in small intestinal biopsy specimens from a clinical material. Scand J Gastroenterol. 1968;3(2):177–182. doi: 10.3109/00365526809180119. [DOI] [PubMed] [Google Scholar]
- McMichael H. B., Webb J., Dawson A. M. Jejunal disaccharidases and some observations on the cause of lactase deficiency. Br Med J. 1966 Oct 29;2(5521):1037–1041. doi: 10.1136/bmj.2.5521.1037. [DOI] [PMC free article] [PubMed] [Google Scholar]
- SAMLOFF I. M., DAVIS J. S., SCHENK E. A. A CLINICAL AND HISTOCHEMICAL STUDY OF CELIAC DISEASE BEFORE AND DURING A GLUTEN-FREE DIET. Gastroenterology. 1965 Feb;48:155–172. [PubMed] [Google Scholar]
- SPIRO H. M., FILIPE M. I., STEWART J. S., BOOTH C. C., PEARSE A. G. FUNCTIONAL HISTOCHEMISTRY OF THE SMALL BOWEL MUCOSA IN MALABSORPTIVE SYNDROMES. Gut. 1964 Apr;5:145–154. doi: 10.1136/gut.5.2.145. [DOI] [PMC free article] [PubMed] [Google Scholar]