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. 1977 Jun;18(6):468–471. doi: 10.1136/gut.18.6.468

Effect of secretin on plasma motilin in man.

P Mitznegg, S R Bloom, W Domschke, W H Haecki, S Domschke, D Belohlavek, E Wünsch, L Demling
PMCID: PMC1411507  PMID: 17563

Abstract

Graded doses of 0-1, 0-3, 0-9, and 2-7 clinical units/kg/h of pure synthetic secretin were infused over 60 minute periods in six healthy volunteers. Duodenal bicarbonate output and pH were recorded and plasma secretin and motilin levels were measured by radioimmunoassay. During the infusions plasma motilin fell in a dose dependent manner to a nadir of 35%. This fall was linearly correlated with pancreatic bicarbonate output, whereas a non-linear correlation was observed between plasma motilin and both plasma secretin level and duodenal pH. It is suggested that plasma motilin levels are decreased by secretin-induced pancreatic bicarbonate juice flow. This may be important for the control of motilin secretion initiated by duodenal acidification and the concomitant delay in gastric emptying.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bloom S. R., Mitznegg P., Bryant M. G. Measurement of human plasma motilin. Scand J Gastroenterol Suppl. 1976;39:47–52. [PubMed] [Google Scholar]
  2. Brown J. C., Mutt V., Dryburgh J. R. The further purification of motilin, a gastric motor activity stimulating polypeptide from the mucosa of the small intestine of hogs. Can J Physiol Pharmacol. 1971 May;49(5):399–405. doi: 10.1139/y71-047. [DOI] [PubMed] [Google Scholar]
  3. Dryburgh J. R., Brown J. C. Radioimmunoassay for motilin. Gastroenterology. 1975 May;68(5 Pt 1):1169–1176. [PubMed] [Google Scholar]
  4. Haecki W. H., Belohlavek D., Bloom S. R., Demling L., Domschke W. Proceedings: Secretin pharmacokinetics and plasma levels for half maximum bicarbonate response in man. Gut. 1976 May;17(5):393–393. [PubMed] [Google Scholar]
  5. Lehnert P., Stahlheber H., Roder O., Zoelch M., Forell M. M., Wünsch E., Jaeger E., Martens H. L. Bestimmung der biologischen Aktivität von synthetischem Secretin. Klin Wochenschr. 1973 Jan;51(1):44–46. doi: 10.1007/BF01484145. [DOI] [PubMed] [Google Scholar]
  6. Mitznegg P., Bloom S. R., Domschke W., Domschke S., Wuensch E., Demling L. Pharmacokinetics of motilin in man. Gastroenterology. 1977 Mar;72(3):413–416. [PubMed] [Google Scholar]
  7. Mitznegg P., Bloom S. R., Domschke W., Domschke S., Wunsch E., Demling L. Release of motilin after duodenal acidification. Lancet. 1976 Apr 24;1(7965):888–889. doi: 10.1016/s0140-6736(76)92101-2. [DOI] [PubMed] [Google Scholar]
  8. Ruppin H., Domschke S., Domschke W., Wünsch E., Jaeger E., Demling L. Effects of 13-nle-motilin in man--inhibition of gastric evacuation and stimulation of pepsin secretion. Scand J Gastroenterol. 1975;10(2):199–202. [PubMed] [Google Scholar]
  9. Thompson J. C., Reeder D. D., Bunchman H. H., Becker H. D., Brandt E. N., Jr Effect of secretin on circulating gastrin. Ann Surg. 1972 Sep;176(3):384–393. doi: 10.1097/00000658-197209000-00014. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Tympner F., Domschke S., Domschke W., Classen M., Demling L. Reproducibility of the response to secretin and secretin plus pancreozymin in man. Scand J Gastroenterol. 1974;9(4):377–381. [PubMed] [Google Scholar]
  11. Wünsch E., Jaeger E., Deffner M., Scharf R., Lehnert P. Zur Synthese des Sekretins. VI. Reindarstellung des synthetischen Sekretins. Chem Ber. 1972;105(8):2515–2522. doi: 10.1002/cber.19721050811. [DOI] [PubMed] [Google Scholar]

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