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. 1977 Sep;18(9):688–691. doi: 10.1136/gut.18.9.688

Can hepatic coma be caused by a reduction of brain noradrenaline or dopamine?

L Zieve, R L Olsen
PMCID: PMC1411646  PMID: 342358

Abstract

Intraventricular infusions of octopamine which raised brain octopamine concentrations more than 20 000-fold resulted in reductions in brain noradrenaline and dopamine by as much as 90% without affecting the alertness or activity of normal rats. As this reduction of brain catecholamines is much greater than any reported in hepatic coma, we do not believe that values observed in experimental hepatic failure have aetiological significance for the encephalopathy that ensues.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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