Abstract
Because somatostatin (SRIF) reduces exocrine pancreatic secretion, its effect on acute pancreatitis was investigated in rats. Linear SRIF reduced serum amylase and lipase but had no effect on pancreatic necrosis, oedema, leucocyte infiltration, and enzyme content. The mortality rate was not reduced. These results do not recommend the use of SRIF in the treatment of acute pancreatitis.
Full text
PDF



Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Adams J. T., Libertino J. A., Schwartz S. I. Significance of an elevated serum amylase. Surgery. 1968 Jun;63(6):877–884. [PubMed] [Google Scholar]
- Boden G., Sivitz M. C., Owen O. E., Essa-Koumar N., Landor J. H. Somatostatin suppresses secretin and pancreatic exocrine secretion. Science. 1975 Oct 10;190(4210):163–165. doi: 10.1126/science.1166308. [DOI] [PubMed] [Google Scholar]
- Brooks F. P. Testing pancreatic function. N Engl J Med. 1972 Feb 10;286(6):300–303. doi: 10.1056/NEJM197202102860605. [DOI] [PubMed] [Google Scholar]
- CLOSE J. R., STREET H. V. An ultra-micro method for determination of amylase activity in blood serum. Clin Chim Acta. 1958 Sep;3(5):476–479. doi: 10.1016/0009-8981(58)90041-x. [DOI] [PubMed] [Google Scholar]
- Condon R. E., Woods J. H., Poulin T. L., Wagner W. G., Pissiotis C. A. Experimental pancreatitis treated with glucagon or lactated Ringer solution. Arch Surg. 1974 Aug;109(2):154–158. doi: 10.1001/archsurg.1974.01360020016004. [DOI] [PubMed] [Google Scholar]
- Creutzfeldt W., Lankisch P. G., Fölsch U. R. Hemmung der Sekretin-und Cholezystokinin-Pankreozymin-induzierten Saft-und Enzymsekretion des Pankreas und der Gallenblasenkontraktion beim Menschen durch Somatostatin. Dtsch Med Wochenschr. 1975 May 16;100(20):1135–1138. [PubMed] [Google Scholar]
- Dollinger H. C., Raptis S., Pfeiffer E. F. Effects of somatostatin on exocrine and endocrine pancreatic function stimulated by intestinal hormones in man. Horm Metab Res. 1976 Jan;8(1):74–78. doi: 10.1055/s-0028-1093677. [DOI] [PubMed] [Google Scholar]
- Dyck W. P., Texter E. C., Jr, Lasater J. M., Hightower N. C., Jr Influence of glucagon on pancreatic exocrine secretion in man. Gastroenterology. 1970 Apr;58(4):532–539. [PubMed] [Google Scholar]
- Dürr H. K., Zelder O., Maroske D., Bode J. C. Zur Behandlung der akuten Pankreatitis mit Glucagon, Bericht über eine Doppelblindstudie. Verh Dtsch Ges Inn Med. 1976;82(Pt 1):970–973. [PubMed] [Google Scholar]
- ERLANGER B. F., KOKOWSKY N., COHEN W. The preparation and properties of two new chromogenic substrates of trypsin. Arch Biochem Biophys. 1961 Nov;95:271–278. doi: 10.1016/0003-9861(61)90145-x. [DOI] [PubMed] [Google Scholar]
- Knight M. J., Condon J. R., Smith R. Possible use of glucagon in the treatment of pancreatitis. Br Med J. 1971 May 22;2(5759):440–442. doi: 10.1136/bmj.2.5759.440. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Lankisch P. G., Arnold R., Creuzfeldt W. Wirkung von Somatostatin auf die betazol-stimulierte Magensekretion und die carbachol-stimulierte Pankreassekretion und Gallenblasenkontraktion des Menschen. Dtsch Med Wochenschr. 1975 Sep 5;100(36):1797–1800. [PubMed] [Google Scholar]
- Lankisch P. G., Winckler K., Bokermann M., Schmidt H., Creutzfeldt W. The influence of glucagon on acute experimental pancreatitis in the rat. Scand J Gastroenterol. 1974 Nov;9(8):725–729. [PubMed] [Google Scholar]
- Rick W. Kinetischer Test zur Bestimmung der Serumlipaseaktivität. Z Klin Chem Klin Biochem. 1970 Sep 8;7(5):530–539. [PubMed] [Google Scholar]
- STREET H. V., CLOSE J. R. Determination of amylase activity in biological fluids. Clin Chim Acta. 1956 May-Jun;1(3):256–268. doi: 10.1016/0009-8981(56)90072-9. [DOI] [PubMed] [Google Scholar]
- Schmidt H., Hesch R. D., Hüfner M., Paschen K., Creutzfeldt W. Hemmung der exokrinen Pankreassekretion des Menschen durch Calcitonin. Dtsch Med Wochenschr. 1971 Nov 5;96(45):1773–1775. [PubMed] [Google Scholar]
