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. 1977 Oct;18(10):779–785. doi: 10.1136/gut.18.10.779

Immunohistochemistry of carcinoembryonic antigen: characterisation of cross-reactions with other glycoproteins.

P Isaacson, M A Judd
PMCID: PMC1411693  PMID: 73495

Abstract

In the course of demonstrating carcinoembryonic antigen (CEA) in normal human small intestine cross-reactivity of specific antiserum against red blood cells, vascular endothelium, and Paneth cell granules was noted. Pretreatment of sections with periodic acid eliminated these cross-reactions without affecting the staining of CEA, indicating that the antigenic determinants shared between CEA and other glycoproteins are in the carbohydrate portion of the molecules. These findings emphasise the caution with which immunohistochemical results should be regarded even when they are apparently well controlled.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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