Skip to main content
PMC home page
Gut logoLink to Gut
. 1977 Oct;18(10):827–832. doi: 10.1136/gut.18.10.827

Maximum acid output to graded doses of pentagastrin and its relation to parietal cell mass in Chinese patients with duodenal ulcer.

F C Cheng, S K Lam, G B Ong
PMCID: PMC1411694  PMID: 590841

Abstract

In groups of Chinese patients with duodenal ulcer and controls, increasing the dose of pentagastrin from the standard dose of 6 ug/kg or 12 ug/kg did not result in any change in the maximum acid output (MAO). Comparison of the MAO thus obtained with that reported in series of Occidental subjects suggested that the Chinese subjects had smaller MAO. Using the method of Card and Marks (1960), the parietal cells of resected stomachs were counted in a group of Chinese patients with duodenal ulcer. It was found that the parietal cell mass (PCM) correlated with the MAO, both PCM and MAO were significantly small in the Chinese series as compared with the Scottish series, but the acid output per unit parietal cell mass (MAO per 10(9) parietal cells) was not different in the two groups. These observations suggested that the Chinese patients with duodenal ulcer had smaller parietal cell mass compared with the Westerners.

Full text

PDF
827

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BARON J. H. Studies of basal and peak acid output with an augmented histamine test. Gut. 1963 Jun;4:136–144. doi: 10.1136/gut.4.2.136. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Baron J. H. The clinical use of gastric function tests. Scand J Gastroenterol Suppl. 1970;6:9–46. [PubMed] [Google Scholar]
  3. CARD W. I., MARKS I. N. The relationship between the acid output of the stomach following "maximal" histamine stimulation and the parietal cell mass. Clin Sci. 1960 Feb;19:147–163. [PubMed] [Google Scholar]
  4. Desai H. G., Anta P., Gupte U. V., Potnis P. R. Dose of histamine for maximal stimulation of gastric acid secretion. Modified subcutaneous histamine test. Gastroenterology. 1969 Dec;57(6):636–640. [PubMed] [Google Scholar]
  5. Fung W. P. Gastric acid secretion in Chinese with particular reference to the dose of histamine required for maximal stimulation. Gut. 1970 Nov;11(11):955–961. doi: 10.1136/gut.11.11.955. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Goyal R. K., Gupta P. S., Chuttani K. H. Gastric acid secretion in Indians with particular reference to the ratio of basal to maximal acid output. Gut. 1966 Dec;7(6):619–623. doi: 10.1136/gut.7.6.619. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Hobsley M., Whitfield P. F., Faber R. G., Parkin J. V. Hypersecretion and length of history in duodenal ulceration. Lancet. 1975 Jul 19;2(7925):101–104. doi: 10.1016/s0140-6736(75)90005-7. [DOI] [PubMed] [Google Scholar]
  8. Johnston D., Jepson K. Use of pentagastrin in a test of gastric acid secretion. Lancet. 1967 Sep 16;2(7516):585–588. doi: 10.1016/s0140-6736(67)90739-8. [DOI] [PubMed] [Google Scholar]
  9. KAY A. W. Effect of large doses of histamine on gastric secretion of HCI; an augmented histamine test. Br Med J. 1953 Jul 11;2(4827):77–80. doi: 10.1136/bmj.2.4827.77. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Lam S. K., Sircus W. Studies on duodenal ulcer. I. The clinical evidence for the existence of two populations. Q J Med. 1975 Apr;44(174):369–387. [PubMed] [Google Scholar]
  11. Novis B. H., Marks I. N., Bank S., Sloan A. W. The relation between gastric acid secretion and body habitus, blood groups, smoking, and the subsequent development of dyspepsia and duodenal ulcer. Gut. 1973 Feb;14(2):107–112. doi: 10.1136/gut.14.2.107. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Vakiland B. J., Mulekar A. M. Studies with the maximal histamine test. Gut. 1965 Aug;6(4):364–371. doi: 10.1136/gut.6.4.364. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Wormsley K. G., Grossman M. I. Maximal histalog test in control subjects and patients with peptic ulcer. Gut. 1965 Oct;6(5):427–435. doi: 10.1136/gut.6.5.427. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from Gut are provided here courtesy of BMJ Publishing Group

RESOURCES