Skip to main content
NCBI home page
Gut logoLink to Gut
. 1978 Mar;19(3):202–206. doi: 10.1136/gut.19.3.202

Increased sensitivity of gastrin release to adrenaline in duodenal ulcer.

O Brandsborg, N J Christensen, N A Løvgreen, M Brandsborg, J F Rehfeld
PMCID: PMC1411909  PMID: 631642

Abstract

Serum gastrin concentrations were measured in patients with duodenal ulcer and controls before, during, and after one-hour intravenous infusion of various doses of adrenaline (0.12 microgram to 6 microgram/min). Gastrin concentrations in the basal state were significantly increased in duodenal ulcer patients compared to controls. The maximal rise in serum gastrin concentrations was obtained at a dose of 4 microgram/min adrenaline in both groups of subjects, and the increase was significantly higher in duodenal ulcer patients than in controls. Adrenaline increased predominantly the gastrin III component (gastrin-17 like) in both duodenal ulcer patients and controls. The threshold level of adrenaline-induced gastrin release was significantly lower in duodenal ulcer patients: intravenous infusion of adrenaline in a dose of 0.12 microgram and 0.25 microgram/min increased serum gastrin concentrations 23 and 43%, respectively, but had no effect in controls. Rises in plasma adrenaline concentrations were similar in both groups of subjects in response to the various doses of adrenaline employed. Only the smallest dose of adrenaline (0.12 microgram/min) resulted in clearly physiological variations in plasma adrenaline concentrations. The results indicate that endogenous adrenaline may stimulate the secretion of gastrin during physiological conditions in patients with duodenal ulcer.

Full text

PDF
202

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Brandsborg O., Brandsborg M., Christensen N. J. Plasma adrenaline and serum gastrin: studies in insulin-induced hypoglycemia and after adrenaline infusions. Gastroenterology. 1975 Mar;68(3):455–460. [PubMed] [Google Scholar]
  2. Brandsborg O., Brandsborg M., Christensen N. J. The role of the beta-adrnergic receptor in the secretion of gastrin: studies in normal subjects and in patients with duodenal ulcers. Eur J Clin Invest. 1976 Sep 10;6(5):395–401. doi: 10.1111/j.1365-2362.1976.tb00534.x. [DOI] [PubMed] [Google Scholar]
  3. Christensen K. C., Stadil F. Effect of epinephrine and norepinephrine on gastrin release and gastric secretion of acid in man. Scand J Gastroenterol Suppl. 1976;37:87–92. [PubMed] [Google Scholar]
  4. Christensen N. J., Brandsborg O. The effect of standing and exercise on plasma catecholamines, serum insulin, and serum gastrin. Scand J Clin Lab Invest. 1976 Oct;36(6):591–595. doi: 10.1080/00365517609054483. [DOI] [PubMed] [Google Scholar]
  5. Christensen N. J., Brandsborg O. The relationship between plasma catecholamine concentration and pulse rate during exercise and standing. Eur J Clin Invest. 1973 Jul;3(4):299–306. doi: 10.1111/j.1365-2362.1973.tb00355.x. [DOI] [PubMed] [Google Scholar]
  6. Christensen N. J. Plasma noradrenaline and adrenaline in patients with thyrotoxicosis and myxoedema. Clin Sci Mol Med. 1973 Aug;45(2):163–171. doi: 10.1042/cs0450163. [DOI] [PubMed] [Google Scholar]
  7. Creutzfeldt W., Arnold R., Creutzfeldt C., Track N. S. Mucosal gastrin concentration, molecular forms of gastrin, number and ultrastructure of G-cells in patients with duodenal ulcer. Gut. 1976 Oct;17(10):745–754. doi: 10.1136/gut.17.10.745. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Dockray G. J., Taylor I. L. Heptadecapeptide gastrin: measurement in blood by specific radioimmunoassay. Gastroenterology. 1976 Dec;71(6):971–977. [PubMed] [Google Scholar]
  9. Engelman K., Portnoy B. A sensitive double-isotope derivative assay for norepinephrine and epinephrine. Normal resting human plasma levels. Circ Res. 1970 Jan;26(1):53–57. doi: 10.1161/01.res.26.1.53. [DOI] [PubMed] [Google Scholar]
  10. Galbo H., Holst J. J., Christensen N. J., Hilsted J. Glucagon and plasma catecholamines during beta-receptor blockade in exercising man. J Appl Physiol. 1976 Jun;40(6):855–863. doi: 10.1152/jappl.1976.40.6.855. [DOI] [PubMed] [Google Scholar]
  11. Hayes J. R., Kennedy T. L., Ardill J., Shanks R. G., Buchanan K. D. Stimulation of gastrin release by catecholamines. Lancet. 1972 Apr 15;1(7755):819–821. doi: 10.1016/s0140-6736(72)90802-1. [DOI] [PubMed] [Google Scholar]
  12. Kaess H., Kuntzen O., Teckentrupp U., Dörner M. The influences of propranolol on serum gastrin concentration and hydrochloric acid secretion in response to hypoglycemia in normal subjects. Digestion. 1975;13(4):193–200. doi: 10.1159/000197708. [DOI] [PubMed] [Google Scholar]
  13. Kronborg O., Pedersen T., Stadil F., Rehfeld J. F. The effect of beta-adrenergic blockade upon gastric acid secretion and gastrin secretion during hypoglycaemia before and after vagotomy. Scand J Gastroenterol. 1974;9(2):173–176. [PubMed] [Google Scholar]
  14. Rehfeld J. F. Disturbed islet-cell function related to endogenous gastrin release. Studies on insulin secretion and glucose tolerance in pernicious anemia. J Clin Invest. 1976 Jul;58(1):41–49. doi: 10.1172/JCI108457. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Rehfeld J. F., Stadil F., Rubin B. Production and evaluation of antibodies for the radioimmunoassay of gastrin. Scand J Clin Lab Invest. 1972 Oct;30(2):221–232. doi: 10.3109/00365517209081114. [DOI] [PubMed] [Google Scholar]
  16. Stadil F., Rehfeld J. F. Preparation of 125 I-labelled synthetic human gastrin I for radioimmunoanalysis. Scand J Clin Lab Invest. 1972 Dec;30(4):361–368. doi: 10.3109/00365517209080271. [DOI] [PubMed] [Google Scholar]
  17. Stadil F., Rehfeld J. F. Release of gastrin by epinephrine in man. Gastroenterology. 1973 Aug;65(2):210–215. [PubMed] [Google Scholar]

Articles from Gut are provided here courtesy of BMJ Publishing Group

RESOURCES