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. 1978 Apr;19(4):277–283. doi: 10.1136/gut.19.4.277

Effects of a protein meal, intraduodenal HCl, and oleic acid on portal and peripheral venous secretin and on pancreatic bicarbonate secretion.

G Boden, R M Wilson, N Essa-Koumar, O E Owen
PMCID: PMC1411928  PMID: 25827

Abstract

We have studied the effect of a protein meal on secretin (IRS) concentration in dogs and humans using a radioimmunoassay of improved sensitivity (8 pg/ml). After a meal, pancreatic bicarbonate secretion (PBS) increased markedly and proximal duodenal pH decreased from 6.2 to 4.3. Portal and peripheral IRS concentrations, however, remained unchanged in eight dogs and five patients with cirrhosis of the liver. Similarly, an alkaline solution of sodium oleate (pH 9.2) stimulated PBS but not IRS. Intraduodenal administration of various amounts of HCl in dogs demonstrated that acid-stimulated PBS was invariably accompanied by rises in peripheral venous IRS concentration. We conclude that the postprandial stimulation of PBS involves mechanisms more complex than acid-stimulated secretin release.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Boden G., Chey W. Y. Preparation and specificity of antiserum to synthetic secretin and its use in a radioimmunoassay (RIA). Endocrinology. 1973 Jun;92(6):1617–1624. doi: 10.1210/endo-92-6-1617. [DOI] [PubMed] [Google Scholar]
  2. Boden G., Essa N., Owen O. E. Effects of intraduodenal amino acids, fatty acids, and sugars on secretin concentrations. Gastroenterology. 1975 Apr;68(4 Pt 1):722–727. [PubMed] [Google Scholar]
  3. Boden G., Essa N., Owen O. E., Reichle F. A. Effects of intraduodenal administration of HCl and glucose on circulating immunoreactive secretin and insulin concentrations. J Clin Invest. 1974 Apr;53(4):1185–1193. doi: 10.1172/JCI107657. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Boden G., Shore L. S., Wilson R. M., Essa-Koumar N., Landor J. H. Effects of Na pentobarbital anesthesia on serum secretin and exocrine pancreatic secretions. Horm Metab Res. 1977 Mar;9(2):123–127. doi: 10.1055/s-0028-1093559. [DOI] [PubMed] [Google Scholar]
  5. Brooks A. M., Grossman M. I. Postprandial pH and neutralizing capacity of the proximal duodenum in dogs. Gastroenterology. 1970 Jul;59(1):85–89. [PubMed] [Google Scholar]
  6. Brown J. C., Harper A. A., Scratcherd T. Potentiation of secretin stimulation of the pancreas. J Physiol. 1967 Jun;190(3):519–530. doi: 10.1113/jphysiol.1967.sp008225. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Cooke A. R., Nahrwold D. L., Grossman M. I. Diversion of pancreatic juice on gastric and pancreatic response to a meal stimulus. Am J Physiol. 1967 Sep;213(3):637–639. doi: 10.1152/ajplegacy.1967.213.3.637. [DOI] [PubMed] [Google Scholar]
  8. Henriksen F. W., Worning H. External pancreatic response to food and its relation to the maximal secretory capacity in dogs. Gut. 1969 Mar;10(3):209–214. doi: 10.1136/gut.10.3.209. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Herrera F., Kemp D. R., Tsukamoto M., Woodward E. R., Dragstedt L. R. A new cannula for the study of pancreatic function. J Appl Physiol. 1968 Aug;25(2):207–209. doi: 10.1152/jappl.1968.25.2.207. [DOI] [PubMed] [Google Scholar]
  10. Kolts B. E., McGuigan J. E. Radioimmunoassay measurement of secretin half-life in man. Gastroenterology. 1977 Jan;72(1):55–60. [PubMed] [Google Scholar]
  11. Lee K. Y., Tai H. H., Chey W. Y. Plasma secretin and gastrin responses to a meat meal and duodenal acidification in dogs. Am J Physiol. 1976 Mar;230(3):784–789. doi: 10.1152/ajplegacy.1976.230.3.784. [DOI] [PubMed] [Google Scholar]
  12. Meyer J. H., Jones R. S. Canine pancreatic responses to intestinally perfused fat and products of fat digestion. Am J Physiol. 1974 May;226(5):1178–1187. doi: 10.1152/ajplegacy.1974.226.5.1178. [DOI] [PubMed] [Google Scholar]
  13. Meyer J. H., Spingola J., Grossman M. I. Endogenous cholecystokinin potentiates exogenous secretin on pancreas of dog. Am J Physiol. 1971 Sep;221(3):742–747. doi: 10.1152/ajplegacy.1971.221.3.742. [DOI] [PubMed] [Google Scholar]
  14. Preshaw R. M., Cooke A. R., Grossman M. I. Quantitative aspects of response of canine pancreas to duodenal acidification. Am J Physiol. 1966 Mar;210(3):629–634. doi: 10.1152/ajplegacy.1966.210.3.629. [DOI] [PubMed] [Google Scholar]
  15. Schaffalitzky de Muckadell O. B., Fahrenkrug J. Radioimmunoassay of secretin in plasma. Scand J Clin Lab Invest. 1977 Apr;37(2):155–162. doi: 10.1080/00365517709156071. [DOI] [PubMed] [Google Scholar]

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