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. 1971 Dec;12(12):984–987. doi: 10.1136/gut.12.12.984

Changes of the smooth endoplasmic reticulum induced by rifampicin in human and guinea-pig hepatocytes 1

A M Jezequel, F Orlandi, L T Tenconi
PMCID: PMC1412001  PMID: 5157136

Abstract

Rifampicin induces a proliferation of the smooth endoplasmic reticulum in guinea-pig and human hepatocytes. This may support the hypothesis of enhancement of drug-metabolizing enzymes induced by the drug. However, the pattern of proliferation is not similar in man and in guinea-pig hepatocytes. Some caution is needed in the study of enzyme induction in man and in extrapolations from animal to human data.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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