Abstract
A group of patients with only moderately active chronic hepatitis has been studied. The follow-up was long (mean 87 months). All patients except one were treated with prednisone and/or azathioprine. Of the hepatitis B virus positive patients two-thirds developed cirrhosis between the second and fifth year of evolution, while in the hepatitis B negative group this occurred in less than one-third. The transition to cirrhosis was clinically silent. The patients were all allowed to do their normal work except in the terminal stages of cirrhosis. Five patients died of causes related to the disease: three patients with cirrhosis and hepatocellular carcinoma, one with gallbladder carcinoma, and one from bleeding varices. The high incidence of tumour, especially liver-cell carcinoma, may be due to a cumulative effect of the presence of hepatitis B virus, cirrhotic transformation, and immuno-suppression. The other patients are currently in apparently good health.
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- Alpert M. E., Hutt M. S., Davidson C. S. Primary hepatoma in Uganda. A prospective clinical and epidemiologic study of forty-six patients. Am J Med. 1969 May;46(5):794–802. doi: 10.1016/0002-9343(69)90030-8. [DOI] [PubMed] [Google Scholar]
- De Groote J., Desmet V. J., Gedigk P., Korb G., Popper H., Poulsen H., Scheuer P. J., Schmid M., Thaler H., Uehlinger E. A classification of chronic hepatitis. Lancet. 1968 Sep 14;2(7568):626–628. doi: 10.1016/s0140-6736(68)90710-1. [DOI] [PubMed] [Google Scholar]
- Dubois R. S., Silverman A., Slovis T. L. Chronic active hepatitis in children. Am J Dig Dis. 1972 Jul;17(7):575–582. doi: 10.1007/BF02231742. [DOI] [PubMed] [Google Scholar]
- Fox R. A., Niazi S. P., Sherlock S. Hepatitis-associated antigen in chronic liver disease. Lancet. 1969 Sep 20;2(7621):609–612. doi: 10.1016/s0140-6736(69)90324-9. [DOI] [PubMed] [Google Scholar]
- Hadziyannis S. J., Merikas G. E., Afroudakis A. P. Hepatitis-associated antigen in chronic liver disease. Lancet. 1970 Jul 11;1(7663):100–100. doi: 10.1016/s0140-6736(70)92672-3. [DOI] [PubMed] [Google Scholar]
- Henning H., Tripatzis I., von Braun H. H., Lüders C. J. [Hepatitis-B-antigen in chronic liver diseases (author's transl)]. Med Klin. 1973 Nov 16;68(46):1503–1510. [PubMed] [Google Scholar]
- Mistilis S. P., Blackburn C. R. Active chronic hepatitis. Am J Med. 1970 Apr;48(4):484–495. doi: 10.1016/0002-9343(70)90049-5. [DOI] [PubMed] [Google Scholar]
- Ray M. B., Desmet V. J., Fevery J., De Groote J., Bradburne A. F., Desmyter J. Distribution patterns of hepatitis B surface antigen (HBsAg) in the liver of hepatitis patients. J Clin Pathol. 1976 Feb;29(2):94–100. doi: 10.1136/jcp.29.2.94. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Ray M. B., Desmet V. J., Fevery J., De Groote J., Bradburne A. F., Desmyter J. Hepatitis B surface antigen (HBsAg) in the liver of patients with hepatitis; a comparison with serological detection. J Clin Pathol. 1976 Feb;29(2):89–93. doi: 10.1136/jcp.29.2.89. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Reed W. D., Stern R. B., Eddleston A. L., Williams R., Zuckerman A. J., Bowes A., Earl P. M. Detection of hepatitis-B antigen by radioimmunoassay in chronic liver disease and hepatocellular carcinoma in Great Britain. Lancet. 1973 Sep 29;2(7831):690–694. doi: 10.1016/s0140-6736(73)92534-8. [DOI] [PubMed] [Google Scholar]
- Wewalka F. G. Protracted and recurrent forms of viral hepatitis. Am J Dis Child. 1972 Apr;123(4):283–286. doi: 10.1001/archpedi.1972.02110100015006. [DOI] [PubMed] [Google Scholar]
- Wright R., McCollum R. W., Klatskin G. Australia antigen in acute and chronic liver disease. Lancet. 1969 Jul 19;2(7612):117–121. doi: 10.1016/s0140-6736(69)92437-4. [DOI] [PubMed] [Google Scholar]
- Wright R., Rassam S. The immunology of acute and chronic hepatitis. Clin Gastroenterol. 1976 May;5(2):387–417. [PubMed] [Google Scholar]