Abstract
This paper reviews the experience gained over the past few years in two techniques of liver support, charcoal haemoperfusion and polyacrylonitrile membrane haemodialysis. Problems with charcoal haemoperfusion have centred around platelet aggregation and hypertension, and new carbon preparations with a variety of different coatings to overcome these problems are described. Haemodialysis using the PAN membrane has caused fewer side-effects and current results show that 33% of patients so treated recover consciousness. The new techniques for liver support currently being developed, including combined dialysis/perfusion systems and those based on plasma separation, are also described.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Andrade J. D., Kunitomo K., Van Wagenen R., Kastigir B., Gough D., Kolff W. J. Coated adsorbents for direct blood perfusion: HEMA-activated carbon. Trans Am Soc Artif Intern Organs. 1971;17:222–228. [PubMed] [Google Scholar]
- Blume U., Helmstaedt D., Sybrecht G., Baldamus C., Sussmann P., Heyer U., Schmidt E., Schmidt F. W. Hämoperfusionstherapie des akuten Leberversagens. Dtsch Med Wochenschr. 1976 Apr;101(14):559–559. [PubMed] [Google Scholar]
- Castino F., Scheucher K., Malchesky P. S., Koshino I., Nosé Y. Microemboli-free blood detoxification utilizing plasma filtration. Trans Am Soc Artif Intern Organs. 1976;22:637–645. [PubMed] [Google Scholar]
- Chang T. M. Removal of endogenous and exogenous toxins by a microencapsulated absorbent. Can J Physiol Pharmacol. 1969 Dec;47(12):1043–1045. doi: 10.1139/y69-170. [DOI] [PubMed] [Google Scholar]
- Chirito E., Reiter B., Lister C., Chang T. M. Artificial liver: the effect of ACAC microencapsulated charcoal hemoperfusion on fulminant hepatic failure. Artif Organs. 1977 Aug;1(1):76–83. doi: 10.1111/j.1525-1594.1977.tb00972.x. [DOI] [PubMed] [Google Scholar]
- Dunlop E. H., Weston M. J., Gazzard B. G., Langley P. G., Mellon P. J., Williams R. Artificial liver support based on haemoperfusion of adsorbents. Biomed Eng. 1975 Jun;10(6):213–218. [PubMed] [Google Scholar]
- Gazzard B. G., Weston M. J., Murray-Lyon I. M., Flax H., Record C. O., Williams R., Portmann B., Langley P. G., Dunlop E. H., Mellon P. J. Charcoal haemoperfusion in the treatment of fulminant hepatic failure. Lancet. 1974 Jun 29;1(7870):1301–1307. doi: 10.1016/s0140-6736(74)90678-3. [DOI] [PubMed] [Google Scholar]
- Opolon P., Lavallard M. C., Crubille C., Gateau P., Nusinovici V., Granger A., Darnis F., Caroli J. Encéphalopathie au cours de l'atrophie hépatique aiguë. Effet de l'épuration des moyennes molécules. Résultats préliminaires. Nouv Presse Med. 1975 Dec 6;4(42):2987–2991. [PubMed] [Google Scholar]
- Opolon P., Lavallard M. C., Huguet C., Bidallier M., Granger A., Gallot D., Bloch P. Hemodialysis versus cross hemodialysis in experimental hepatic coma. Surg Gynecol Obstet. 1976 Jun;142(6):845–853. [PubMed] [Google Scholar]
- Silk D. B., Williams R. Experiences in the treatment of fulminant hepatic failure by conservative therapy, charcoal haemoperfusion, and polyacrylonitrile haemodialysis. Int J Artif Organs. 1978 Jan;1(1):29–33. [PubMed] [Google Scholar]
- Weston M. J., Gazzard B. G., Buxton B. H., Winch J., Machado A. L., Flax H., Williams R. Effects of haemoperfusion through charcoal or XAD-2 resin on an animal model of fulminant liver failure. Gut. 1974 Jun;15(6):482–486. doi: 10.1136/gut.15.6.482. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Weston M. J., Langley P. G., Rubin M. H., Hanid M. A., Mellon P., Williams R. Platelet function in fulminant hepatic failure and effect of charcoal haemoperfusion. Gut. 1977 Nov;18(11):897–902. doi: 10.1136/gut.18.11.897. [DOI] [PMC free article] [PubMed] [Google Scholar]
- YATZIDIS H., OREOPOULOS D., TRIANTAPHYLLIDIS D., VOUDICLARI S., TSAPARAS N., GAVRAS C., STAVROULAKI A. TREATMENT OF SEVERE BARBITURATE POISONING. Lancet. 1965 Jul 31;2(7405):216–217. doi: 10.1016/s0140-6736(65)90698-7. [DOI] [PubMed] [Google Scholar]