Skip to main content
PMC home page
Gut logoLink to Gut
. 1978 Jul;19(7):606–610. doi: 10.1136/gut.19.7.606

Low dose steroids and clinical relapse in Crohn's disease: a controlled trial.

R C Smith, J Rhodes, R V Heatley, L E Hughes, D L Crosby, B I Rees, H Jones, K T Evans, B W Lawrie
PMCID: PMC1412084  PMID: 355071

Abstract

The long-term effect of prednisone in Crohn's disease has been examined in a double-blind controlled trial. Clinical relapse, recurrence, and extension of the disease were examined in 64 patients followed-up for up to three years. Fourteen patients were withdrawn because of severe symptoms (eight on prednisone and six controls); the withdrawal rate in both groups was 30% at three years. Nine other patients had radiological recurrence or extension of disease (five prednisone and four controls). Prednisone did not improve the relapse rate, nor did it affect recurrence or extension of disease.

Full text

PDF

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Best W. R., Becktel J. M., Singleton J. W., Kern F., Jr Development of a Crohn's disease activity index. National Cooperative Crohn's Disease Study. Gastroenterology. 1976 Mar;70(3):439–444. [PubMed] [Google Scholar]
  2. COOKE W. T. Nutritional and metabolic factors in the aetiology and treatment of regional ileitis; Hunterian lecture delivered at the Royal College of Surgeons of England on 28th April 1955. Ann R Coll Surg Engl. 1955 Sep;17(3):137–158. [PMC free article] [PubMed] [Google Scholar]
  3. Cooke W. T., Fielding J. F. Corticosteroid or corticotrophin therapy in Crohn's disease (regional enteritis). Gut. 1970 Nov;11(11):921–927. doi: 10.1136/gut.11.11.921. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. De Dombal F. T., Burton I., Goligher J. C. Recurrence of Crohn's disease after primary excisional surgery. Gut. 1971 Jul;12(7):519–527. doi: 10.1136/gut.12.7.519. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Jones J. H., Lennard-Jones J. E. Corticosteroids and corticotrophin in the treatment of Crohn's disease. Gut. 1966 Apr;7(2):181–187. doi: 10.1136/gut.7.2.181. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Lennard-Jones J. E., Stalder G. A. Prognosis after resection of chronic regional ileitis. Gut. 1967 Aug;8(4):332–336. doi: 10.1136/gut.8.4.332. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Peto R., Pike M. C., Armitage P., Breslow N. E., Cox D. R., Howard S. V., Mantel N., McPherson K., Peto J., Smith P. G. Design and analysis of randomized clinical trials requiring prolonged observation of each patient. I. Introduction and design. Br J Cancer. 1976 Dec;34(6):585–612. doi: 10.1038/bjc.1976.220. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Peto R., Pike M. C., Armitage P., Breslow N. E., Cox D. R., Howard S. V., Mantel N., McPherson K., Peto J., Smith P. G. Design and analysis of randomized clinical trials requiring prolonged observation of each patient. II. analysis and examples. Br J Cancer. 1977 Jan;35(1):1–39. doi: 10.1038/bjc.1977.1. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Rosenberg J. L., Levin B., Wall A. J., Kirsner J. B. A controlled trial of azathioprine in Crohn's disease. Am J Dig Dis. 1975 Aug;20(8):721–726. doi: 10.1007/BF01070829. [DOI] [PubMed] [Google Scholar]
  10. VAN PATTER W. N., BARGEN J. A., DOCKERTY M. B., FELDMAN W. H., MAYO C. W., WAUGH J. M. Regional enteritis. Gastroenterology. 1954 Mar;26(3):347–450. [PubMed] [Google Scholar]
  11. Willoughby J. M., Beckett J., Kumar P. J., Dawson A. M. Controlled trial of azathioprine in Crohn's disease. Lancet. 1971 Oct 30;2(7731):944–947. doi: 10.1016/s0140-6736(71)90268-6. [DOI] [PubMed] [Google Scholar]

Articles from Gut are provided here courtesy of BMJ Publishing Group

RESOURCES