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. 1972 Mar;13(3):197–200. doi: 10.1136/gut.13.3.197

Effect of spironolactone on stool electrolyte losses during human cholera

Richard L Guerrant, Lincoln C Chen, Jon E Rohde
PMCID: PMC1412119  PMID: 5024724

Abstract

This study demonstrated that endogenous aldosterone, as determined by its transient competitive block by spironolactone, caused significant sodium and chloride retention during naturally acquired cholera. This beneficial effect of the hormone is accompanied, however, by a deleterious depletion of potassium. In addition, it was found that stool rate significantly altered the sodium and potassium concentrations in cholera stool despite minimal or absent aldosterone activity.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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