Skip to main content
Gut logoLink to Gut
. 1972 Mar;13(3):182–188. doi: 10.1136/gut.13.3.182

Intestinal bacterial flora and bile salt studies in hypogammaglobulinaemia

D M Parkin, D B L McClelland, R R O'Moore, I W Percy-Robb, I W B Grant, D J C Shearman
PMCID: PMC1412127  PMID: 5024722

Abstract

Five patients with adult acquired hypogammaglobulinaemia, four of whom were achlorhydric, were studied. Jejunal bacterial counts were much higher than those in a control group of acid secretors, but were similar to those in a control group of patients with pernicious anaemia; Giardia lamblia were isolated from the jejunal content of all patients with hypogammaglobulinaemia. The concentration of conjugated bile acids in the fasting state was lower in hypogammaglobulinaemia than in pernicious anaemia, but in the two hypogammaglobulinaemic patients with steatorrhoea there was a normal bile salt response to a fatty meal.

Full text

PDF
182

Images in this article

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Badley B. W., Murphy G. M., Bouchier I. A. Intraluminal bile-salt deficiency in the pathogenesis of steatorrhoea. Lancet. 1969 Aug 23;2(7617):400–402. doi: 10.1016/s0140-6736(69)90111-1. [DOI] [PubMed] [Google Scholar]
  2. Binder H. J., Reynolds R. D. Control of diarrhea in secondary hypogammaglobulinemia by fresh plasma infusions. N Engl J Med. 1967 Oct 12;277(15):802–803. doi: 10.1056/NEJM196710122771507. [DOI] [PubMed] [Google Scholar]
  3. COLLINS J. R., ELLIS D. S. AGAMMAGLOBULINEMIA, MALABSORPTION AND RHEUMATOID-LIKE ARTHRITIS. Am J Med. 1965 Sep;39:476–482. doi: 10.1016/0002-9343(65)90214-7. [DOI] [PubMed] [Google Scholar]
  4. Crabbé P. A., Heremans J. F. Selective IgA deficiency with steatorrhea. A new syndrome. Am J Med. 1967 Feb;42(2):319–326. doi: 10.1016/0002-9343(67)90031-9. [DOI] [PubMed] [Google Scholar]
  5. DAWSON A. M., ISSELBACHER K. J. Studies on lipid metabolism in the small intestine with observations on the role of bile salts. J Clin Invest. 1960 May;39:730–740. doi: 10.1172/JCI104090. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Dietschy J. M. Effects of bile salts on intermediate metabolism of the intestinal mucosa. Fed Proc. 1967 Nov-Dec;26(6):1589–1598. [PubMed] [Google Scholar]
  7. Dubois R. S., Roy C. C., Fulginiti V. A., Merrill D. A., Murray R. L. Disaccharidase deficiency in children with immunologic deficits. J Pediatr. 1970 Mar;76(3):377–385. doi: 10.1016/s0022-3476(70)80476-0. [DOI] [PubMed] [Google Scholar]
  8. FAHEY J. L., MCKELVEY E. M. QUANTITATIVE DETERMINATION OF SERUM IMMUNOGLOBULINS IN ANTIBODY-AGAR PLATES. J Immunol. 1965 Jan;94:84–90. [PubMed] [Google Scholar]
  9. Finlayson N. D., Simpson J. D., Tothill P., Samson R. R., Girdwood R. H., Shearman D. J. Application of whole body counting to the measurement of vitamin B12 absorption with reference to achlorhydria. Scand J Gastroenterol. 1969;4(5):397–405. doi: 10.3109/00365526909180624. [DOI] [PubMed] [Google Scholar]
  10. GREEN I., SPERBER R. J. Hypogammaglobulinemia, arthritis, sprue, and megaloblastic anemia. N Y State J Med. 1962 May 15;62:1679–1686. [PubMed] [Google Scholar]
  11. Gorbach S. L., Tabaqchali S. Bacteria, bile, and the small bowel. Gut. 1969 Dec;10(12):963–972. doi: 10.1136/gut.10.12.963. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Gryboski J. D., Self T. W., Clemett A., Herskovic T. Selective immunoglobulin A deficiency and intestinal nodular lymphoid hyperplasia: correction of diarrhea with antibiotics and plasma. Pediatrics. 1968 Nov;42(5):833–837. [PubMed] [Google Scholar]
  13. Hermans P. E., Huizenga K. A., Hoffman H. N., Brown A. L., Jr, Markowitz H. Dysgammaglobulinemia associated with nodular lymphoid hyperplasia of the small intestine. Am J Med. 1966 Jan;40(1):78–89. doi: 10.1016/0002-9343(66)90189-6. [DOI] [PubMed] [Google Scholar]
  14. Hersh T., Floch M. H., Binder H. J., Conn H. O., Prizont R., Spiro H. M. Disturbance of the jejunal and colonic bacterial flora in immunoglobulin deficiencies. Am J Clin Nutr. 1970 Dec;23(12):1595–1601. doi: 10.1093/ajcn/23.12.1595. [DOI] [PubMed] [Google Scholar]
  15. KRITCHEVSKY D., MARTAK D. S., ROTHBLAT G. H. Detection of bile acids in thin-layer chromatography. Anal Biochem. 1963 May;5:388–392. doi: 10.1016/0003-2697(63)90040-x. [DOI] [PubMed] [Google Scholar]
  16. Low-Beer T. S., Schneider R. E., Dobbins W. O. Morphological changes of the small-intestinal mucosa of guinea pig and hamster following incubation in vitro and perfusion in vivo with unconjugated bile salts. Gut. 1970 Jun;11(6):486–492. doi: 10.1136/gut.11.6.486. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Mawas C., Sors C., Bernier J. J. Amyloidosis associated with primary agammaglobulinemia, severe diarrhea and familial hypogammaglobulinemia. Am J Med. 1969 Apr;46(4):624–634. doi: 10.1016/0002-9343(69)90081-3. [DOI] [PubMed] [Google Scholar]
  18. McCarthy C. F., Austad W. I., Read A. E. Hypogammaglobulinemia and steatorrhea. Am J Dig Dis. 1965 Nov;10(11):945–957. doi: 10.1007/BF02236010. [DOI] [PubMed] [Google Scholar]
  19. ROGOSA M., FITZGERALD R. J., MACKINTOSH M. E., BEAMAN A. J. Improved medium for selective isolation of Veillonella. J Bacteriol. 1958 Oct;76(4):455–456. doi: 10.1128/jb.76.4.455-456.1958. [DOI] [PMC free article] [PubMed] [Google Scholar]
  20. ROGOSA M., MITCHELL J. A., WISEMAN R. F. A selective medium for the isolation and enumeration of oral and fecal lactobacilli. J Bacteriol. 1951 Jul;62(1):132–133. doi: 10.1128/jb.62.1.132-133.1951. [DOI] [PMC free article] [PubMed] [Google Scholar]
  21. Rosen F. S., Janeway C. A. The gamma globulins. 3. The antibody deficiency syndromes. N Engl J Med. 1966 Sep 29;275(13):709–contd. doi: 10.1056/NEJM196609292751307. [DOI] [PubMed] [Google Scholar]
  22. SHERWOOD W. C., GOLSTEIN F., HAURANI F. I., WIRTS C. W. STUDIES OF THE SMALL-INTESTINAL BACTERIAL FLORA AND OF INTESTINAL ABSORPTION IN PERNICIOUS ANEMIA. Am J Dig Dis. 1964 Jun;9:416–425. doi: 10.1007/BF02239334. [DOI] [PubMed] [Google Scholar]
  23. Tomasi T. B., Jr On the mechanisms of transport and biological significance of antibodies in external secretions. Arthritis Rheum. 1969 Feb;12(1):45–50. doi: 10.1002/art.1780120108. [DOI] [PubMed] [Google Scholar]
  24. Twomey J. J., Jordan P. H., Jr, Laughter A. H., Meuwissen H. J., Good R. A. The gastric disorder in immunoglobulin-deficient patients. Ann Intern Med. 1970 Apr;72(4):499–504. doi: 10.7326/0003-4819-72-4-499. [DOI] [PubMed] [Google Scholar]
  25. Van Deest B. W., Fordtran J. S., Morawski S. G., Wilson J. D. Bile salt and micellar fat concentration in proximal small bowel contents of ileectomy patients. J Clin Invest. 1968 Jun;47(6):1314–1324. doi: 10.1172/JCI105823. [DOI] [PMC free article] [PubMed] [Google Scholar]
  26. WILLIS A. T., HOBBS G. Some new media for the isolation and identification of Clostridia. J Pathol Bacteriol. 1959 Apr;77(2):511–521. doi: 10.1002/path.1700770223. [DOI] [PubMed] [Google Scholar]

Articles from Gut are provided here courtesy of BMJ Publishing Group

RESOURCES