Skip to main content
Gut logoLink to Gut
. 1972 Mar;13(3):211–219. doi: 10.1136/gut.13.3.211

Mass peristalsis in the human colon after contact with oxyphenisatin

James Ritchie
PMCID: PMC1412133  PMID: 5024726

Abstract

Colonic motility studies using time-lapse cinefluorography and intraluminal pressure recording before and after the introduction per rectum of a mixture of barium sulphate and oxyphenisatin solution show the different forms of movement of the colonic contents.

Oxyphenisatin was found to be a selective actuator of a form of progressive mass propulsion indistinguishable from spontaneous mass peristalsis. Less than 0·5 mg distributed through the pelvic and distal descending colon was enough to produce a peristaltic response; larger quantities tended to increase the number of resulting movements.

A standard dose of 4 mg of the drug was followed by mass peristalsis in 82% of the subjects in whom it came into adequate contact with colonic mucosa. The response usually took place within 20 minutes. The more sensitive the subject, the greater was the number of peristaltic responses and the shorter the interval before the response began.

In 73% of the subjects who responded, the mass peristalsis came to a halt between 40 and 25 cm from the anal margin, and many of those in whom it extended farther appeared to have shortened distal colons. The likelihood of the drug giving rise to peristalsis diminished abruptly distal to about 45 cm from the anus; its effectiveness was greatest in the proximal descending colon.

Full text

PDF
211

Images in this article

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bayliss W. M., Starling E. H. The movements and the innervation of the large intestine. J Physiol. 1900 Dec 31;26(1-2):107–118. doi: 10.1113/jphysiol.1900.sp000825. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Hardcastle J. D., Mann C. V. Physical factors in the stimulation of colonic peristalsis. Gut. 1970 Jan;11(1):41–46. doi: 10.1136/gut.11.1.41. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Ritchie J. A. Colonic motor activity and bowel function. I. Normal movement of contents. Gut. 1968 Aug;9(4):442–456. doi: 10.1136/gut.9.4.442. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Ritchie J. A., Truelove S. C., Ardan G. M., Tuckey M. S. Propulsion and retropulsion of normal colonic contents. Am J Dig Dis. 1971 Aug;16(8):697–704. doi: 10.1007/BF02239592. [DOI] [PubMed] [Google Scholar]

Articles from Gut are provided here courtesy of BMJ Publishing Group

RESOURCES