Skip to main content
Gut logoLink to Gut
. 1978 Aug;19(8):748–753. doi: 10.1136/gut.19.8.748

Peliosis hepatis in recipients of renal transplants.

C Degott, B Rueff, H Kreis, A Duboust, F Potet, J P Benhamou
PMCID: PMC1412137  PMID: 355072

Abstract

Peliosis hepatis, an uncommon liver lesion characterised by blood-filled cavities bordered by hepatocytic plates, was found in 12 patients three to 17 months after renal transplantation. Hepatomegaly and portal hypertension were present in five of the six patients with major peliosis hepatis, and were absent in the other six with minor hepatic lesions. Alterations of centrilobular vein walls in some of these patients suggest that peliosis hepatis could be the result of a blockade or liver blood outflow at the junctions of sinusoids and centrilobular veins. The cause of these alterations might be azathioprine.

Full text

PDF
748

Images in this article

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BRAS G., JELLIFFE D. B., STUART K. L. Veno-occlusive disease of liver with nonportal type of cirrhosis, occurring in Jamaica. AMA Arch Pathol. 1954 Apr;57(4):285–300. [PubMed] [Google Scholar]
  2. Bagheri S. A., Boyer J. L. Peliosis hepatis associated with androgenic-anabolic steroid therapy. A severe form of hepatic injury. Ann Intern Med. 1974 Nov;81(5):610–618. doi: 10.7326/0003-4819-81-5-610. [DOI] [PubMed] [Google Scholar]
  3. Berne T. V., Chatterjee S. N., Craig J. R., Payne J. E. Hepatic dysfunction in recipients of renal allografts. Surg Gynecol Obstet. 1975 Aug;141(2):171–175. [PubMed] [Google Scholar]
  4. Bernstein M. S., Hunter R. L., Yachnin S. Hepatoma and peliosis hepatis developing in a patient with Fanconi's anemia. N Engl J Med. 1971 May 20;284(20):1135–1136. doi: 10.1056/NEJM197105202842006. [DOI] [PubMed] [Google Scholar]
  5. CAROLI J., JULIEN C., ALBANO O. P'ELIOSE H'EPATIQUE ET PLASMOSARCOMATOSE SPL'ENIQUE. PREMI'ERE OBSERVATION RECONNUE "IN VIVO". Sem Hop. 1964 Jun 14;40:1709–1720. [PubMed] [Google Scholar]
  6. CLARK P. A., HSIA Y. E., HUNTSMAN R. G. Toxic complications of treatment with 6-mercaptopurine; two cases with hepatic necrosis and intestinal ulceration. Br Med J. 1960 Feb 6;1(5170):393–395. doi: 10.1136/bmj.1.5170.393. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. De Groote J., Desmet V. J., Gedigk P., Korb G., Popper H., Poulsen H., Scheuer P. J., Schmid M., Thaler H., Uehlinger E. A classification of chronic hepatitis. Lancet. 1968 Sep 14;2(7568):626–628. doi: 10.1016/s0140-6736(68)90710-1. [DOI] [PubMed] [Google Scholar]
  8. Delage C., Lagacé R. La péliose hépatique: rôle étiologique possible des médicaments. Union Med Can. 1973 Sep;102(9):1888–1893. [PubMed] [Google Scholar]
  9. Evans D. B., Millard P. R., Herbertson B. M. Hepatic dysfunction associated with renal transplantation. Lancet. 1968 Nov 2;2(7575):929–933. doi: 10.1016/s0140-6736(68)91165-3. [DOI] [PubMed] [Google Scholar]
  10. Griner P. F., Elbadawi A., Packman C. H. Veno-occlusive disease of the liver after chemotherapy of acute leukemia. Report of two cases. Ann Intern Med. 1976 Nov;85(5):578–582. doi: 10.7326/0003-4819-85-5-578. [DOI] [PubMed] [Google Scholar]
  11. HAMILTON F. T., LUBITZ J. M. Peliosis hepatis; report of three cases, with discussion of pathogenesis. AMA Arch Pathol. 1952 Dec;54(6):564–572. [PubMed] [Google Scholar]
  12. Hoyumpa A. M., Jr, Schiff L., Helfman E. L. Budd-Chiari syndrome in women taking oral contraceptives. Am J Med. 1971 Jan;50(1):137–140. doi: 10.1016/0002-9343(71)90213-0. [DOI] [PubMed] [Google Scholar]
  13. KENT G., THOMPSON J. R. Peliosis hepatis; involvement of reticuloendothelial system. Arch Pathol. 1961 Dec;72:658–664. [PubMed] [Google Scholar]
  14. Kühböck J., Radaszkiewicz T., Walek H. Peliosis hepatis, eine Komplikation der Anabolikatherapie. Med Klin. 1975 Oct 3;70(40):1602–1607. [PubMed] [Google Scholar]
  15. Lebrec D., Degott C., Rueff B., Benhamou J. P. Transvenous (transjugular) liver biopsy. An experience based on 100 biopsies. Am J Dig Dis. 1978 Apr;23(4):302–304. doi: 10.1007/BF01072410. [DOI] [PubMed] [Google Scholar]
  16. Marubbio A. T., Danielson B. Hepatic veno-occlusive disease in a renal transplant patient receiving azathioprine. Gastroenterology. 1975 Sep;69(3):739–743. [PubMed] [Google Scholar]
  17. Naeim F., Copper P. H., Semion A. A. Peliosis hepatis. Possible etiologic role of anabolic steroids. Arch Pathol. 1973 Apr;95(4):284–285. [PubMed] [Google Scholar]
  18. Nielsen V., Clausen E., Ranek L. Liver impairment during chronic hemodialysis and after renal transplantation. Acta Med Scand. 1975 Mar;197(3):229–234. doi: 10.1111/j.0954-6820.1975.tb04907.x. [DOI] [PubMed] [Google Scholar]
  19. Orandi M., Pirozynski W. J. Peliosis hepatis. Can Med Assoc J. 1967 Apr 29;96(17):1219–1220. [PMC free article] [PubMed] [Google Scholar]
  20. Paradinas F. J., Bull T. B., Westaby D., Murray-Lyon I. M. Hyperplasia and prolapse of hepatocytes into hepatic veins during longterm methyltestosterone therapy: possible relationships of these changes to the developement of peliosis hepatis and liver tumours. Histopathology. 1977 Jul;1(4):225–246. doi: 10.1111/j.1365-2559.1977.tb01663.x. [DOI] [PubMed] [Google Scholar]
  21. Putzke H. P., Persaud T. V., Bienengräber A. Fine structure of the liver in experimental veno-occlusive disease. Exp Pathol (Jena) 1972;6(5):325–332. [PubMed] [Google Scholar]
  22. STEIN H., ISAACSON C. Veno-occlusive disease of the liver. Br Med J. 1962 Feb 10;1(5275):372–374. doi: 10.1136/bmj.1.5275.372. [DOI] [PMC free article] [PubMed] [Google Scholar]
  23. Stuart F. P., Torres E., Hester W. J., Dammin G. J., Moore F. D. Orthotopic autotransplantation and allotransplantation of the liver: functional and structural patterns in the dog. Ann Surg. 1967 Mar;165(3):325–340. doi: 10.1097/00000658-196703000-00001. [DOI] [PMC free article] [PubMed] [Google Scholar]
  24. TRITES A. E. Peliosis hepatis; report of a case. AMA Arch Pathol. 1957 Feb;63(2):183–186. [PubMed] [Google Scholar]
  25. Torisu M., Yokoyama T., Amemiya H., Kohler P. F., Schroter G., Martineau G., Penn I., Palmer W., Halgrimson C. G., Putnam C. W. Immunosuppression, liver injury, and hepatitis in renal, hepatic, and cardiac homograft recipients: with particular reference to the Australia antigen. Ann Surg. 1971 Oct;174(4):620–639. doi: 10.1097/00000658-197110000-00008. [DOI] [PMC free article] [PubMed] [Google Scholar]
  26. Ware A. J., Luby J. P., Eigenbrodt E. H., Long D. L., Hull A. R. Spectrum of liver disease in renal transplant recipients. Gastroenterology. 1975 Apr;68(4 Pt 1):755–764. [PubMed] [Google Scholar]
  27. Westaby D., Ogle S. J., Paradinas F. J., Randell J. B., Murray-Lyon I. M. Liver damage from long-term methyltestosterone. Lancet. 1977 Aug 6;2(8032):262–263. [PubMed] [Google Scholar]
  28. Winkler K., Poulsen H. Liver disease with periportal sinusoidal dilatation. A possible complication to contraceptive steroids. Scand J Gastroenterol. 1975;10(7):699–704. [PubMed] [Google Scholar]
  29. YANOFF M., RAWSON A. J. PELIOSIS HEPATIS. AN ANATOMIC STUDY WITH DEMONSTRATION OF TWO VARIETIES. Arch Pathol. 1964 Feb;77:159–165. [PubMed] [Google Scholar]
  30. ZAK F. G. Peliosis hepatis. Am J Pathol. 1950 Jan;26(1):1-15, incl 2 pl. [PMC free article] [PubMed] [Google Scholar]

Articles from Gut are provided here courtesy of BMJ Publishing Group

RESOURCES