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. 1972 Jul;13(7):520–523. doi: 10.1136/gut.13.7.520

An enteroglucagon tumour

S R Bloom
PMCID: PMC1412275  PMID: 5069726

Abstract

A hormone-secreting renal tumour that affected small bowel structure, motility, and function has been described by Gleeson et al (1971). The present studies show that the large amount of glucagon-like immunoreactivity which could be extracted from this tumour had the molecular weight, action on plasma insulin and glucose in vivo, and immunological reactions of the gut hormone enteroglucagon. This is the first enteroglucagonoma to be reported.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Dyck W. P. Influence of intrajejunal glucose on pancreatic exocrine function in man. Gastroenterology. 1971 May;60(5):864–869. [PubMed] [Google Scholar]
  2. GREENWOOD F. C., HUNTER W. M., GLOVER J. S. THE PREPARATION OF I-131-LABELLED HUMAN GROWTH HORMONE OF HIGH SPECIFIC RADIOACTIVITY. Biochem J. 1963 Oct;89:114–123. doi: 10.1042/bj0890114. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Gleeson M. H., Bloom S. R., Polak J. M., Henry K., Dowling R. H. Endocrine tumour in kidney affecting small bowel structure, motility, and absorptive function. Gut. 1971 Oct;12(10):773–782. doi: 10.1136/gut.12.10.773. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Heding L. G. The production of glucagon antibodies in rabbits. Horm Metab Res. 1969 Mar;1(2):87–88. doi: 10.1055/s-0028-1096828. [DOI] [PubMed] [Google Scholar]
  5. KENNY A. J. Extractable glucagon of the human pancreas. J Clin Endocrinol Metab. 1955 Sep;15(9):1089–1105. doi: 10.1210/jcem-15-9-1089. [DOI] [PubMed] [Google Scholar]
  6. Marco J., Faloona G. R., Unger R. H. Effect of endogenous intestinal glucagon-like immunoreactivity (GLI) on insulin secretion and glucose concentration in dogs. J Clin Endocrinol Metab. 1971 Aug;33(2):318–325. doi: 10.1210/jcem-33-2-318. [DOI] [PubMed] [Google Scholar]
  7. Persson I., Gyntelberg F., Heding L. G., Boss-Nielsen J. Pancreatic-glucagon-like immunoreactivity after intravenous insulin in normals and chronic-pancreatitis patients. Acta Endocrinol (Copenh) 1971 Jun;67(2):401–404. doi: 10.1530/acta.0.0670401. [DOI] [PubMed] [Google Scholar]
  8. Polak J. M., Bloom S., Coulling I., Pearse A. G. Immunofluorescent localization of enteroglucagon cells in the gastrointestinal tract of the dog. Gut. 1971 Apr;12(4):311–318. doi: 10.1136/gut.12.4.311. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Samols E., Tyler J., Marri G., Marks V. Stimulation of glucagon secretion by oral glucose. Lancet. 1965 Dec 18;2(7425):1257–1259. doi: 10.1016/s0140-6736(65)92278-6. [DOI] [PubMed] [Google Scholar]
  10. UNGER R. H., EISENTRAUT A. M., McCALL M. S., MADISON L. L. Glucagon antibodies and an immunoassay for glucagon. J Clin Invest. 1961 Jul;40:1280–1289. doi: 10.1172/JCI104357. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Unger R. H., Ohneda A., Valverde I., Eisentraut A. M., Exton J. Characterization of the responses of circulating glucagon-like immunoreactivity to intraduodenal and intravenous administration of glucose. J Clin Invest. 1968 Jan;47(1):48–65. doi: 10.1172/JCI105714. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Valverde I., Rigopoulou D., Exton J., Ohneda A., Eisentraut A., Unger R. H. Demonstration and characterization of a second fraction of glucagon-like immunoreactivity in jejunal extracts. Am J Med Sci. 1968 Jun;255:415–420. doi: 10.1097/00000441-196806000-00007. [DOI] [PubMed] [Google Scholar]
  13. Valverde I., Rigopoulou D., Marco J., Faloona G. R., Unger R. H. Molecular size of extractable glucagon and glucagon-like immunoreactivity (GLI) in plasma. Diabetes. 1970 Sep;19(9):624–629. doi: 10.2337/diab.19.9.624. [DOI] [PubMed] [Google Scholar]

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