Abstract
In a randomised double-blind trial over one year oral BCG has been compared with a control preparation in the treatment of chronic Crohn's disease. Overall assessment scores deteriorated in nine of 22 patients taking BCG, and 11 of 26 in the control group (P = 0.25); this deterioration was great enough to be regarded as a clinical relapse in three patients taking BCG and in seven taking the control preparation (P greater than 0.1). No significant benefit from oral BCG treatment has been demonstrated.
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- Best W. R., Becktel J. M., Singleton J. W., Kern F., Jr Development of a Crohn's disease activity index. National Cooperative Crohn's Disease Study. Gastroenterology. 1976 Mar;70(3):439–444. [PubMed] [Google Scholar]
- Klein M., Binder H. J., Mitchell M., Aaronson R., Spiro H. Treatment of Crohn's disease with azathioprine: a controlled evaluation. Gastroenterology. 1974 May;66(5):916–922. [PubMed] [Google Scholar]
- Mackaness G. B., Auclair D. J., Lagrange P. H. Immunopotentiation with BCG. I. Immune response to different strains and preparations. J Natl Cancer Inst. 1973 Nov;51(5):1655–1667. doi: 10.1093/jnci/51.5.1655. [DOI] [PubMed] [Google Scholar]
- Ng R. P., Vicary F. R. Cell-mediated immunity and transfer factor in Crohn's disease. Br Med J. 1976 Jul 10;2(6027):87–88. doi: 10.1136/bmj.2.6027.87-a. [DOI] [PMC free article] [PubMed] [Google Scholar]
- O'Donoghue D. P., Dawson A. M., Powell-Tuck J., Bown R. L., Lennard-Jones J. E. Double-blind withdrawal trial of azathioprine as maintenance treatment for Crohn's disease. Lancet. 1978 Nov 4;2(8097):955–957. doi: 10.1016/s0140-6736(78)92524-2. [DOI] [PubMed] [Google Scholar]
- Rhodes J., Bainton D., Beck P., Campbell H. Controlled trial of azathioprine in Crohn's disease. Lancet. 1971 Dec 11;2(7737):1273–1276. doi: 10.1016/s0140-6736(71)90598-8. [DOI] [PubMed] [Google Scholar]
- Rosenberg J. L., Levin B., Wall A. J., Kirsner J. B. A controlled trial of azathioprine in Crohn's disease. Am J Dig Dis. 1975 Aug;20(8):721–726. doi: 10.1007/BF01070829. [DOI] [PubMed] [Google Scholar]
- Segal A. W., Levi A. J., Loewi G. Levamisole in the treatment of Crohn's disease. Lancet. 1977 Aug 20;2(8034):382–385. doi: 10.1016/s0140-6736(77)90307-5. [DOI] [PubMed] [Google Scholar]
- Willoughby J. M., Beckett J., Kumar P. J., Dawson A. M. Controlled trial of azathioprine in Crohn's disease. Lancet. 1971 Oct 30;2(7731):944–947. doi: 10.1016/s0140-6736(71)90268-6. [DOI] [PubMed] [Google Scholar]