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. 1978 Dec;19(12):1144–1147. doi: 10.1136/gut.19.12.1144

Comparison of bran, ispaghula, and lactulose on colon function in diverticular disease.

M A Eastwood, A N Smith, W G Brydon, J Pritchard
PMCID: PMC1412321  PMID: 744500

Abstract

Bran, ispaghula (Fybogel), and lactulose were given to three groups of patients with diverticular disease for four weeks. Faecal weights, bile acids, fat and electrolytes, transit time, and colonic motility were estimated before and after treatment. Stool weight increased, notably with Fybogel. Cereal bran had the greatest effect on the transit time, reducing it significantly. There were no changes in faecal bile acids, fat or electrolytes. Coarse bran reduced colonic motility and the number of high pressure waves after food; Fybogel increased the basal pressure and was without effect on the food-stimulated pressures; whereas lactulose influenced neither. All agents paradoxically equally alleviated symptoms.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Attisha R. P., Smith A. N. Pressure activity of the colon and rectum in diverticular disease before and after sigmoid myotomy. Br J Surg. 1969 Dec;56(12):891–894. doi: 10.1002/bjs.1800561205. [DOI] [PubMed] [Google Scholar]
  2. BOLIN D. W., KING R. P., KLOSTERMAN E. W. A simplified method for the determination of chromic oxide (Cr2 O3) when used as an index substance. Science. 1952 Dec 5;116(3023):634–635. doi: 10.1126/science.116.3023.634. [DOI] [PubMed] [Google Scholar]
  3. Cummings J. H., Branch W., Jenkins D. J., Southgate D. A., Houston H., James W. P. Colonic response to dietary fibre from carrot, cabbage, apple, bran. Lancet. 1978 Jan 7;1(8054):5–9. doi: 10.1016/s0140-6736(78)90357-4. [DOI] [PubMed] [Google Scholar]
  4. Eastwood M. A. Colonic diverticulosis: medical and dietary management. Clin Gastroenterol. 1975 Jan;4(1):85–97. [PubMed] [Google Scholar]
  5. Eastwood M. A., Smith A. N., Brydon W. G., Pritchard J. Colonic function in patients with diverticular disease. Lancet. 1978 Jun 3;1(8075):1181–1182. doi: 10.1016/s0140-6736(78)90969-8. [DOI] [PubMed] [Google Scholar]
  6. Evrard E., Janssen G. Gas-liquid chromatographic determination of human fecal bile acids. J Lipid Res. 1968 Mar;9(2):226–236. [PubMed] [Google Scholar]
  7. Findlay J. M., Mitchell W. D., Eastwood M. A., Anderson A. J., Smith A. N. Intestinal streaming patterns in cholerrhoeic enteropathy and diverticular disease. Gut. 1974 Mar;15(3):207–212. doi: 10.1136/gut.15.3.207. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Findlay J. M., Smith A. N., Mitchell W. D., Anderson A. J., Eastwood M. A. Effects of unprocessed bran on colon function in normal subjects and in diverticular disease. Lancet. 1974 Feb 2;1(7849):146–149. doi: 10.1016/s0140-6736(74)92439-8. [DOI] [PubMed] [Google Scholar]
  9. Hinton J. M., Lennard-Jones J. E., Young A. C. A ne method for studying gut transit times using radioopaque markers. Gut. 1969 Oct;10(10):842–847. doi: 10.1136/gut.10.10.842. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Hodgson J. Effect of methylcellulose on rectal and colonic pressures in treatment of diverticular disease. Br Med J. 1972 Sep 23;3(5829):729–731. doi: 10.1136/bmj.3.5829.729. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Kirwan W. O., Smith A. N., McConnell A. A., Mitchell W. D., Eastwood M. A. Action of different bran preparations on colonic function. Br Med J. 1974 Oct 26;4(5938):187–189. doi: 10.1136/bmj.4.5938.187. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Srivastava G. S., Smith A. N., Painter N. S. Sterculia bulk-forming agent with smooth-muscle relaxant versus bran in diverticular disease. Br Med J. 1976 Feb 7;1(6005):315–318. doi: 10.1136/bmj.1.6005.315. [DOI] [PMC free article] [PubMed] [Google Scholar]

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