Abstract
Pure bovine pancreatic polypeptide (PP) was infused into 23 healthy subjects at doses of 1, 3, and 5 pmol/kg/min over 60 minutes and plasma PP was measured by radioimmunoassay. During the infusions mean plasma levels of 203 +/- 34, 575 +/- 73, and 930 +/- 48 pmol/l respectively were achieved. Mean disappearance half time on stopping the infusion was 6.9 +/- 0.3 min (mean +/- SEM). The metabolic clearance rate was 5.1 +/- 0.2 ml/kg/min (mean +/- SEM) and the apparent volume of distribution was calculated to be 51 +/- 3 ml/kg (mean +/- SEM). This study provides for the first time pharmacokinetic data for PP in man.
Full text
PDFSelected References
These references are in PubMed. This may not be the complete list of references from this article.
- Adrian T. E., Besterman H. S., Cooke T. J., Bloom S. R., Barnes A. J., Russell R. C. Mechanism of pancreatic polypeptide release in man. Lancet. 1977 Jan 22;1(8004):161–163. doi: 10.1016/s0140-6736(77)91762-7. [DOI] [PubMed] [Google Scholar]
- Adrian T. E., Bloom S. R., Bryant M. G., Polak J. M., Heitz P. H., Barnes A. J. Distribution and release of human pancreatic polypeptide. Gut. 1976 Dec;17(12):940–944. doi: 10.1136/gut.17.12.940. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Floyd J. C., Jr, Fajans S. S., Pek S. Regulation in healthy subjects of the secretion of human pancreatic polypeptide, a newly recognized pancreatic islet polypeptide. Trans Assoc Am Physicians. 1976;89:146–158. [PubMed] [Google Scholar]
- Kimmel J. R., Pollock H. G., Hazelwood R. L. Isolation and characterization of chicken insulin. Endocrinology. 1968 Dec;83(6):1323–1330. doi: 10.1210/endo-83-6-1323. [DOI] [PubMed] [Google Scholar]
- Lin T. M., Evans D. C., Chance R. E., Spray G. F. Bovine pancreatic peptide: action on gastric and pancreatic secretion in dogs. Am J Physiol. 1977 Mar;232(3):E311–E315. doi: 10.1152/ajpendo.1977.232.3.E311. [DOI] [PubMed] [Google Scholar]
- Schwartz T. W., Rehfeld J. F., Stadil F., Larson L. I., Chance R. E., Moon N. Pancreatic-polypeptide response to food in duodenal-ulcer patients before and after vagotomy. Lancet. 1976 May 22;1(7969):1102–1105. doi: 10.1016/s0140-6736(76)90065-9. [DOI] [PubMed] [Google Scholar]