Skip to main content
PMC home page
Gut logoLink to Gut
. 1972 Nov;13(11):894–899. doi: 10.1136/gut.13.11.894

The effect of retaining antral innervation on the reductions of gastric acid and pepsin secretion after vagotomy

R J Clarke, R N Allan, J Alexander-Williams
PMCID: PMC1412417  PMID: 4566958

Abstract

The result of a prospective trial of 40 patients with duodenal ulcer treated either by proximal gastric vagotomy (antrum innervated) or by selective vagotomy (antrum denervated) shows that they are equally effective in reducing gastric acid and pepsin secretion.

Preservation of antral innervation by proximal gastric vagotomy reduces gastric secretion as effectively as denervation of the entire stomach.

Full text

PDF
894

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Amdrup E., Jensen H. E. Selective vagotomy of the parietal cell mass preserving innervation of the undrained antrum. A preliminary report of results in patients with duodenal ulcer. Gastroenterology. 1970 Oct;59(4):522–527. [PubMed] [Google Scholar]
  2. Amdrup E., Kragelund E., Humphrey C. S., Smith R. B., Goligher J. C., Johnston D. Evidence for partial vagal reinnervation of the stomach after highly selective vagotomy without a drainage procedure (HSV) for duodenal ulcer in man. Gut. 1971 Oct;12(10):866–866. [PubMed] [Google Scholar]
  3. Bank S., Marks I. N., Louw J. H. Histamine- and insulin-stimulated gastric acid secretion after selective and truncal vagotomy. Gut. 1967 Feb;8(1):36–41. doi: 10.1136/gut.8.1.36. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Baron J. H., Gutierrez L. V., Spencer J., Tinker J., Welbourn R. B. The insulin test in the unoperated subject. Gut. 1969 Dec;10(12):1046–1047. [PubMed] [Google Scholar]
  5. Burge H., MacLean C., Stedeford R., Pinn G., Hollanders D. Selective vagotomy without drainage. An interim report. Br Med J. 1969 Sep 20;3(5672):690–693. doi: 10.1136/bmj.3.5672.690. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Clarke R. J., McFarland J. B., Williams J. A. Gastric stasis and gastric ulcer after selective vagotomy without a drainage procedure. Br Med J. 1972 Feb 26;1(5799):538–539. doi: 10.1136/bmj.1.5799.538. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Gillespie G., Elder J. B., Gillespie I. E., Kay A. W., Campbell E. H. The long term stability of the insulin test. Gastroenterology. 1970 May;58(5):625–632. [PubMed] [Google Scholar]
  8. Goligher J. C., Pulvertaft C. N., Irvin T. T., Johnston D., Walder B., Hall R. A., Willson-Pepper J., Matheson T. S. Five- to eight-year results of truncal vagotomy and pyloroplasty for duodenal ulcer. Br Med J. 1972 Jan 1;1(5791):7–13. doi: 10.1136/bmj.1.5791.7. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Johnston D., Thomas D. G., Checketts R. G., Duthie H. L. An assessment of postoperative testing for completeness of vagotomy. Br J Surg. 1967 Oct;54(10):831–833. doi: 10.1002/bjs.1800541006. [DOI] [PubMed] [Google Scholar]
  10. Johnston D., Wilkinson A. R. Highly selective vagotomy without a drainage procedure in the treatment of duodenal ulcer. Br J Surg. 1970 Apr;57(4):289–296. doi: 10.1002/bjs.1800570414. [DOI] [PubMed] [Google Scholar]
  11. Kay A. W. Memorial lecture: an evaluation of gastric acid secretion tests. Gastroenterology. 1967 Dec;53(6):834–844. [PubMed] [Google Scholar]
  12. Mason M. C., Giles G. R., Graham N. G., Clark C. G., Goligher J. C. An early assessment of selective and total vagotomy. Br J Surg. 1968 Sep;55(9):677–680. doi: 10.1002/bjs.1800550908. [DOI] [PubMed] [Google Scholar]
  13. ROSS B., KAY A. W. THE INSULIN TEST AFTER VAGOTOMY. Gastroenterology. 1964 Apr;46:379–386. [PubMed] [Google Scholar]
  14. Watkin D. F., Duthie H. L. Changes in the postoperative insulin test in relation to recurrent duodenal ulceration. Gut. 1971 Apr;12(4):303–310. doi: 10.1136/gut.12.4.303. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from Gut are provided here courtesy of BMJ Publishing Group

RESOURCES