Skip to main content
PMC home page
Gut logoLink to Gut
. 1979 Jun;20(6):513–517. doi: 10.1136/gut.20.6.513

Effect of 16,16-dimethyl prostaglandin E2 on the gastric mucosal barrier.

J P Bolton, M M Cohen
PMCID: PMC1412452  PMID: 468078

Abstract

16,16-dimethyl prostaglandin E2 (16DM) can protect the gastric mucosa from injury and yet apparently damages the gastric mucosal barrier. The effect on the gastric mucosal barrier of 16DM (26.2 micromol/l), a dose 50 times the ED50 for inhibition of acid secretion, was investigated in Heidenhain pouches in four dogs by measuring plasma shedding from the pouches after the topical application of histamine (2.7 mmol/l) and ionic fluxes. The results were compared with those using 30% ethanol, a known barrier breaker. The topical application of histamine after three hours' perfusion with 30% ethanol led to plasma shedding at a rate of 7.5 (+/-2.6) ml/h, which was significantly greater than the rate of 1.2 (+/-1.4) ml/h after three hours' perfusion with 16DM and of 1.5 (+/-1.7) ml/h in the control group. Ethanol also caused an increase in the flux of H+, Na+, and Cl-, indicating an increase in mucosal permeability, whereas 16DM increased the flux of Na+ and Cl- but not of H+. It is concluded that 16DM does not damage the gastric mucosal barrier but stimulates the secretion of fluid containing Na+ and Cl-.

Full text

PDF
513

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bolton J. P., Cohen M. M. Stimulation of non-parietal cell secretion in canine Heidenhain pouches by 16,16-dimethyl prostaglandin E2. Digestion. 1978 Jul-Aug;17(4):291–299. doi: 10.1159/000198122. [DOI] [PubMed] [Google Scholar]
  2. Bowen J. C., Kuo Y. J., Pawlik W., Williams D., Shanbour L. L., Jacobson E. D. Electrophysiological effects of burimamide and 16,16-dimethyl prostaglandin E2 on the canine gastric mucosa. Gastroenterology. 1975 Jun;68(6):1480–1484. [PubMed] [Google Scholar]
  3. Chung R. S., Field M., Silen W. Permeability of gastric mucosa to hydrogen and lithium. Gastroenterology. 1973 Apr;64(4):593–598. [PubMed] [Google Scholar]
  4. Davenport H. W. Ethanol damage to canine oxyntic glandular mucosa. Proc Soc Exp Biol Med. 1967 Dec;126(3):657–662. doi: 10.3181/00379727-126-32532. [DOI] [PubMed] [Google Scholar]
  5. Davenport H. W. Fluid produced by the gastric mucosa during damage by acetic and salicylic acids. Gastroenterology. 1966 Apr;50(4):487–499. [PubMed] [Google Scholar]
  6. Davenport H. W., Kauffman G. L., Jr Plasma shedding by the canine oxyntic and pyloric glandular mucosa induced by topical action of acetylcholine. Effect of atropine and physostigmine. Gastroenterology. 1975 Jul;69(1):190–197. [PubMed] [Google Scholar]
  7. Fiocca F., Basso N., Passaro E. P., Jr, Speranza V. Effect of histamine on isolated human gastric mucosa. Surg Forum. 1974;25(0):321–323. [PubMed] [Google Scholar]
  8. Fung W. P., Karim S. M., Tye C. Y. Effect of 15(R)15 methylprostaglandin E2 methyl ester on healing of gastric ulcers. Controlled endoscopic study. Lancet. 1974 Jul 6;2(7871):10–12. doi: 10.1016/s0140-6736(74)91346-4. [DOI] [PubMed] [Google Scholar]
  9. Moody F. G., Davis W. L. Hydrogen and sodium permeation of canine gastric mucosa during histamine and sodium thiocyanate administration. Gastroenterology. 1970 Sep;59(3):350–357. [PubMed] [Google Scholar]
  10. O'Brien P. E., Carter D. C. Effect of gastric secretory inhibitors on the gastric mucosal barrier. Gut. 1975 Jun;16(6):437–442. doi: 10.1136/gut.16.6.437. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Rees W. D., Rhodes J., Wheeler M. H., Meek E. M., Williams B., Newcombe R. G. Effect of histamine receptor antagonists on bile damage to the gastric mucosa of canine Heidenhain pouches. Gut. 1977 Oct;18(10):821–826. doi: 10.1136/gut.18.10.821. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Robert A., Schultz J. R., Nezamis J. E., Lancaster C. Gastric antisecretory and antiulcer properties of PGE2, 15-methyl PGE2, and 16, 16-dimethyl PGE2. Intravenous, oral and intrajejunal administration. Gastroenterology. 1976 Mar;70(3):359–370. [PubMed] [Google Scholar]
  13. Saik R. P., Brown D. Lithium: not a sensitive indicator of hydrogen ion diffusion. J Surg Res. 1978 Aug;25(2):163–165. doi: 10.1016/0022-4804(78)90071-9. [DOI] [PubMed] [Google Scholar]

Articles from Gut are provided here courtesy of BMJ Publishing Group

RESOURCES