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. 1979 Jun;20(6):531–537. doi: 10.1136/gut.20.6.531

Idiopathic portal hypertension (perisinusoidal fibrosis) after renal transplantation.

C Nataf, G Feldmann, D Lebrec, C Degott, J M Descamps, B Rueff, J P Benhamou
PMCID: PMC1412455  PMID: 381128

Abstract

We report the cases of two renal transplant recipients suffering from idopathic portal hypertension, a condition characterised by increased portal venous pressure in the absence of both histological lesion of the liver and obstruction of the portal vein. In these two patients, perisnusoidal fibrosis, invisible by light microscopy, was demonstrated by electron microscopy; it is suggested that partial obstruction of hepatic sinusoids by perisinusoidal fibrosis could be the mechanism for increased portal venous pressure in all the patients with idiopathic portal hypertension. In these two patients, who received 6-mercaptopurine and azathioprine, perisinusoidal fibrosis might be the consequence of prolonged administration of these drugs.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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