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. 1979 Jun;20(6):523–525. doi: 10.1136/gut.20.6.523

HLA and cell-mediated immunity in HBsAg negative chronic active hepatitis.

A J Vogten, R G Shorter, G Opelz
PMCID: PMC1412459  PMID: 89064

Abstract

In 20 patients with severe HBsAg negative chronic active hepatitis a significant association has been found between the HLA determinants A1, B8, and Dw3 and cell-mediated immunity directed against human liver specific lipoprotein in vitro. This observation induces further speculation that genetic immunoregulatory action might be involved in the pathogenetic mechanisms of chronic active hepatitis in vivo.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bach F. H., Rood J. J. The major histocompatibility complex--genetics and biology (second of three parts). N Engl J Med. 1976 Oct 14;295(16):872–878. doi: 10.1056/NEJM197610142951606. [DOI] [PubMed] [Google Scholar]
  2. Bach F. H., van Rood J. J. The major histocompatibility complex--genetics and biology. (First of three parts). N Engl J Med. 1976 Oct 7;295(15):806–813. doi: 10.1056/NEJM197610072951504. [DOI] [PubMed] [Google Scholar]
  3. Cochrane A. M., Moussouros A., Smith A., Portmann B., Eddleston A. L., Williams R. Lymphocyte cytotoxicity in chronic active hepatitis: effect of therapy and correlations with clinical and histological changes. Gut. 1978 Apr;19(4):308–314. doi: 10.1136/gut.19.4.308. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Cochrane A. M., Moussouros A., Thomsom A. D., Eddleston A. L., Wiiliams R. Antibody-dependent cell-mediated (K cell) cytotoxicity against isolated hepatocytes in chronic active hepatitis. Lancet. 1976 Feb 28;1(7957):441–444. doi: 10.1016/s0140-6736(76)91472-0. [DOI] [PubMed] [Google Scholar]
  5. Galbraith R. M., Eddleston A. L., Smith M. G., Williams R., McSween R. N., Watkinson G., Dick H., Kennedy L. A., Batchelor J. R. Histocompatibility antigens in active chronic hepatitis and primary biliary cirrhosis. Br Med J. 1974 Sep 7;3(5931):604–605. doi: 10.1136/bmj.3.5931.604. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Geubel A. P., Keller R. H., Summerskill W. H., Dickson E. R., Tomasi T. B., Shorter R. G. Lymphocyte cytotoxicity and inhibition studied with autologous liver cells: observations in chronic active liver disease and the primary biliary cirrhosis syndrome. Gastroenterology. 1976 Sep;71(3):450–456. [PubMed] [Google Scholar]
  7. Hopf U., Meyer zum Büschenfelde K. H. Studies on the pathogenesis of experimental chronic active hepatitis in rabbits. II. Demonstration of immunoglobulin on isolated hepatocytes. Br J Exp Pathol. 1974 Oct;55(5):509–513. [PMC free article] [PubMed] [Google Scholar]
  8. Mackay I. R., Morris P. J. Association of autoimmune active chronic hepatitis with HL-A1,8. Lancet. 1972 Oct 14;2(7781):793–795. doi: 10.1016/s0140-6736(72)92149-6. [DOI] [PubMed] [Google Scholar]
  9. Marx J. L. Immunology: role of immune response genes. Science. 1976 Jan 23;191(4224):277–318. doi: 10.1126/science.191.4224.277. [DOI] [PubMed] [Google Scholar]
  10. Mittal K. K., Mickey M. R., Singal D. P., Terasaki P. I. Serotyping for homotransplantation. 18. Refinement of microdroplet lymphocyte cytotoxicity test. Transplantation. 1968 Nov;6(8):913–927. doi: 10.1097/00007890-196811000-00006. [DOI] [PubMed] [Google Scholar]
  11. Opelz G., Vogten A. J., Summerskill W. H., Schalm S. W., Terasaki P. I. HLA determinants in chronic active liver disease: possible relation of HLA-Dw3 to prognosis. Tissue Antigens. 1977 Jan;9(1):36–40. doi: 10.1111/j.1399-0039.1977.tb01077.x. [DOI] [PubMed] [Google Scholar]
  12. Page A. R., Sharp H. L., Greenberg L. J., Yunis E. J. Genetic analysis of patients with chronic active hepatitis. J Clin Invest. 1975 Sep;56(3):530–535. doi: 10.1172/JCI108121. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Schalm S. W., Ammon H. V., Summerskill W. H. Failure of customary treatment in chronic active liver disease: causes and management. Ann Clin Res. 1976 Jun;8(3):221–227. [PubMed] [Google Scholar]
  14. Soloway R. D., Summerskill W. H., Baggenstoss A. H., Geall M. G., Gitnićk G. L., Elveback I. R., Schoenfield L. J. Clinical, biochemical, and histological remission of severe chronic active liver disease: a controlled study of treatments and early prognosis. Gastroenterology. 1972 Nov;63(5):820–833. [PubMed] [Google Scholar]
  15. Vogten A. J., Hadzic N., Shorter R. G., Summerskill W. H., Taylor W. F. Cell-mediated cytotoxicity in chronic active liver disease: a new test system. Gastroenterology. 1978 May;74(5 Pt 1):883–889. [PubMed] [Google Scholar]

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