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. 1973 Jan;14(1):25–29. doi: 10.1136/gut.14.1.25

Zollinger-Ellison syndrome type 1: clinical and pathological correlations of a case

D J Cowley, I W Dymock, B E Boyes, R Y Wilson, B H Stagg, M R Lewin, Julia M Polak, A G E Pearse
PMCID: PMC1412583  PMID: 4571070

Abstract

Some patients with the Zollinger-Ellison syndrome appear to have hypergastrinaemia and hyperplasia of the antral G cells but no tumour. This subgroup has been classified as Zollinger-Ellison syndrome type 1. We have treated such a patient by vagotomy and antrectomy, the fasting plasma gastrin and acid secretion subsequently returning to normal.

A 17-year-old male had a four-year history of duodenal ulcer. Gastric secretion tests showed acid hypersecretion. Fasting plasma gastrin was 8350 pg/ml (normal 50-170 pg/ml). At laparotomy duodenal ulceration was confirmed but no pancreatic or other tumours were found. Truncal vagotomy and antrectomy was performed with distal pancreatectomy. Immunofluorescent staining showed hyperplasia of G cells in the resected antrum but a normal pancreas and duodenum.

Six months after operation he was symptom free and acid secretion was reduced by 92%. The fasting plasma gastrin at two months was <50 pg/ml.

These findings suggest that type 1 Zollinger-Ellison syndrome may be a clinical entity.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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