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. 1973 Apr;14(4):289–292. doi: 10.1136/gut.14.4.289

Gastric mucosal morphology and faecal blood loss during ethanol ingestion

V P Dinoso Jr, H Meshkinpour, S H Lorber
PMCID: PMC1412595  PMID: 4706910

Abstract

The faecal blood loss of six alcoholic subjects with normal gastric mucosa, six with superficial gastritis, and six with atrophic gastritis was studied before and during ingestion of 40% v/v ethanol using 51Cr-tagged red blood cells. No significant change in faecal blood loss was observed in the normal mucosa and superficial gastritis groups but all subjects with atrophic gastritis had significant increases of faecal blood loss during ethanol ingestion. These observations suggest that gastric mucosal morphology may be an important determinant of gastric mucosal bleeding during the ingestion of alcohol.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Blackman A. H., Lambert D. L., Thayer W. R., Martin H. F. Computed normal values for peak acid output based on age, sex and body weight. Am J Dig Dis. 1970 Sep;15(9):783–789. doi: 10.1007/BF02236035. [DOI] [PubMed] [Google Scholar]
  2. Bouchier I. A., Williams H. S. Determination of faecal blood-loss after combined alcohol and sodium-acetylsalicylate intake. Lancet. 1969 Jan 25;1(7587):178–180. doi: 10.1016/s0140-6736(69)91191-x. [DOI] [PubMed] [Google Scholar]
  3. CROFT D. N., LUBRAN M. THE ESTIMATION OF DEOXYRIBONUCLEIC ACID IN THE PRESENCE OF SIALIC ACID: APPLICATION TO ANALYSIS OF HUMAN GASTRIC WASHINGS. Biochem J. 1965 Jun;95:612–620. doi: 10.1042/bj0950612. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Croft D. N., Pollock D. J., Coghill N. F. Cell loss from human gastric mucosa measured by the estimation of deoxyribonucleic acid (DNA) in gastric washings. Gut. 1966 Aug;7(4):333–343. doi: 10.1136/gut.7.4.333. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Dinoso V. P., Chey W. Y., Siplet H., Lorber S. H. Effects of ethanol on the gastric mucosa of the Heidenhain pouch of dogs. Am J Dig Dis. 1970 Sep;15(9):809–817. doi: 10.1007/BF02236042. [DOI] [PubMed] [Google Scholar]
  6. Goulston K., Cooke A. R. Alcohol, aspirin, and gastrointestinal bleeding. Br Med J. 1968 Dec 14;4(5632):664–665. doi: 10.1136/bmj.4.5632.664. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Harker L. A., Slichter S. J. The bleeding time as a screening test for evaluation of platelet function. N Engl J Med. 1972 Jul 27;287(4):155–159. doi: 10.1056/NEJM197207272870401. [DOI] [PubMed] [Google Scholar]
  8. JOSKE R. A., FINCKH E. S., WOOD I. J. Gastric biopsy; a study of 1,000 consecutive successful gastric biopsies. Q J Med. 1955 Jul;24(95):269–294. [PubMed] [Google Scholar]
  9. Needham C. D., Kyle J., Jones P. F., Johnston S. J., Kerridge D. F. Aspirin and alcohol in gastrointestinal haemorrhage. Gut. 1971 Oct;12(10):819–821. doi: 10.1136/gut.12.10.819. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. PALMER E. D. Gastritis: a revaluation. Medicine (Baltimore) 1954 Sep;33(3):199–290. doi: 10.1097/00005792-195409000-00002. [DOI] [PubMed] [Google Scholar]
  11. WILLIAMS A. W. Effects of alcohol on gastric mucosa. Br Med J. 1956 Feb 4;1(4961):256–259. doi: 10.1136/bmj.1.4961.256. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Winawer S. J., Bejar J., McCray R. S., Zamcheck N. Hemorrhagic gastritis. Importance of associated chronic gastritis. Arch Intern Med. 1971 Jan;127(1):129–131. doi: 10.1001/archinte.127.1.129. [DOI] [PubMed] [Google Scholar]

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