Skip to main content
PMC home page
Gut logoLink to Gut
. 1973 Apr;14(4):293–299. doi: 10.1136/gut.14.4.293

Effect of proximal gastric vagotomy on gastric acid secretion and plasma gastrin

C G Clark, M R Lewin, B H Stagg, J H Wyllie
PMCID: PMC1412600  PMID: 4706911

Abstract

Sixteen patients underwent proximal gastric vagotomy (highly selective vagotomy) for chronic duodenal ulceration. All were subjected to preoperative and postoperative acid secretion studies. A reduction in the secretory response to pentagastrin and abolition of the response to meat extract occurred postoperatively.

Plasma gastrin levels in response to meat extract were studied by radioimmunoassay. Basal plasma gastrin levels were unaffected by vagotomy and it was found that the plasma gastrin response to meat extract was not impaired after operation if the postoperative insulin test was positive. Only if the insulin test was negative was the amount of gastrin released by meat extract reduced.

Full text

PDF

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Byrnes D. J., Lazarus L., Young J. D. Effect of vagotomy on serum gastrin in patients with duodenal ulceration. Australas Ann Med. 1970 Aug;19(3):240–243. doi: 10.1111/imj.1970.19.3.240. [DOI] [PubMed] [Google Scholar]
  2. CLARK C. G. RECOVERY OF GASTRIC FUNCTION AFTER INCOMPLETE VAGOTOMY. Br J Surg. 1964 Jul;51:539–542. doi: 10.1002/bjs.1800510719. [DOI] [PubMed] [Google Scholar]
  3. Clarke R. J. A randomized trial of selective and parietal cell vagotomy without a drainage procedure. Br J Surg. 1971 Nov;58(11):870–871. [PubMed] [Google Scholar]
  4. Forrester J. M., Ganguli P. C. The effect of meat extract (Oxo) on plasma gastrin concentration in human subjects. J Physiol. 1970 Dec;211(2 Suppl):33P+–33P+. [PubMed] [Google Scholar]
  5. Giles G. R., Clark C. G. Gastric secretion stimulated by meat extract in man. Scand J Gastroenterol. 1966;1(3):159–166. doi: 10.1080/00365521.1966.11800629. [DOI] [PubMed] [Google Scholar]
  6. Hassan M. A., Hobsley M. Positioning of subject and of nasogastric tube during a gastric secretion study. Br Med J. 1970 Feb 21;1(5694):458–460. doi: 10.1136/bmj.1.5694.458. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Johnston D., Humphrey C. S., Smith R. B., Wilkinson A. R. Should the gastric antrum be vagally denervated if it is well drained and in the acid stream? Br J Surg. 1971 Oct;58(10):725–731. doi: 10.1002/bjs.1800581004. [DOI] [PubMed] [Google Scholar]
  8. Korman M. G., Hansky J., Coupland G. A., Cumberland V. H. Serum gastrin in duodenal ulcer. IV. Effect of selective gastric vagotomy. Gut. 1972 Mar;13(3):163–165. doi: 10.1136/gut.13.3.163. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Korman M. G., Hansky J., Scott P. R. Serum gastrin in duodenal ulcer. 3. Influence of vagotomy and pylorectomy. Gut. 1972 Jan;13(1):39–42. doi: 10.1136/gut.13.1.39. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Korman M. G., Soveny C., Hansky J. Serum gastrin in duodenal ulcer. I. Basal levels and effect of food and atropine. Gut. 1971 Nov;12(11):899–902. doi: 10.1136/gut.12.11.899. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Kragelund E., Amdrup E., Goligher J. C., Humphrey C. S., Smith R. B., Wilkinson A. R., Johnston D. The insulin test after highly selective vagotomy without drainage for duodenal ulcer. Br J Surg. 1971 Nov;58(11):871–871. [PubMed] [Google Scholar]
  12. McGuigan J. E., Trudeau W. L. Serum gastrin levels before and after vagotomy and pyloroplasty or vagotomy and antrectomy. N Engl J Med. 1972 Jan 27;286(4):184–188. doi: 10.1056/NEJM197201272860404. [DOI] [PubMed] [Google Scholar]
  13. Stadil F. Effect of vagotomy on gastrin release during insulin hypoglycaemia in ulcer patients. Scand J Gastroenterol. 1972;7(3):225–231. doi: 10.3109/00365527209181157. [DOI] [PubMed] [Google Scholar]
  14. Wastell C., MacNaughton J. I., Colin J. F., Gleeson J. Gastric secretion and emptying before and after parietal cell vagotomy, with and without pyloroplasty. Br J Surg. 1971 Nov;58(11):871–871. [PubMed] [Google Scholar]
  15. Wyllie J. H., Boulos P. B., Lewin M. R., Stagg B. H., Clark C. G. Plasma gastrin and acid secretion in man following stimulation by food, meat extract, and insulin. Gut. 1972 Nov;13(11):887–893. doi: 10.1136/gut.13.11.887. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Yalow R. S., Berson S. A. Size and charge distinctions between endogenous human plasma gastrin in peripheral blood and heptadecapeptide gastrins. Gastroenterology. 1970 May;58(5):609–615. [PubMed] [Google Scholar]

Articles from Gut are provided here courtesy of BMJ Publishing Group

RESOURCES