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. 1979 Sep;20(9):775–779. doi: 10.1136/gut.20.9.775

Cell proliferation of pericryptal fibroblasts in the rat colon mucosa.

A P Maskens, J R Rahier, F P Meersseman, R M Dujardin-Loits, J G Haot
PMCID: PMC1412656  PMID: 499917

Abstract

The turnover of pericryptal fibroblasts in the rat colon mucosa was analysed after in vivo incorporation of tritiated thymidine. Thirty-six rats were serially killed one hour to 21 days after intraperitoneal injection of the radionuclide. At one hour, the labelling index of pericryptal fibroblasts was only 2.44%; labelled fibroblasts were slightly predominant along the lower two-thirds of the crypts. Within 24 hours, most underwent at least one cell division. No migration was observed and a significant proportion of labelled fibroblasts was still present after three weeks. It is concluded that those fibroblasts constitute a slowly renewing cell population. The data failed to confirm the hypothesis of an 'en bloc' migration of fibroblasts in synchrony with the epithelial cells.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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