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. 1979 Nov;20(11):971–976. doi: 10.1136/gut.20.11.971

Cigarette smoking, chronic peptic ulceration, and pepsin 1 secretion.

V Walker, W H Taylor
PMCID: PMC1412681  PMID: 118897

Abstract

The relationship between the secretion of pepsin 1 (the most electronegative of the pepsins), and the smoking habits of 219 patients has been investigated. Significantly more cigarette smokers with peptic ulceration (72.5%) secreted pepsin 1 in greater than trace amounts after pentagastrin or histamine than did non-smokers with ulceration (51.2%). Differences of a similar order were found for men with duodenal ulcer, women with duodenal ulcer, and all patients with gastric ulcer, but the difference was statistically significant only for men with duodenal ulcer. Significantly more patients with peptic ulcer smoking six to 15 cigarettes/day secreted moderate or high concentrations of pepsin 1 than did heavier smokers or non-smokers. There was no significant association between cigarette smoking and pepsin 1 secretion among 74 patients without ulceration. Maximal acid output was not significantly related to smoking in any group studied. The findings add to the increasing body of evidence linking pepsins and pepsin 1 with the pathogenesis of peptic ulceration.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. ALLIBONE A., FLINT F. J. Bronchitis, aspirin, smoking, and other factors in the aetiology of peptic ulcer. Lancet. 1958 Jul 26;2(7039):179–182. doi: 10.1016/s0140-6736(58)91526-5. [DOI] [PubMed] [Google Scholar]
  2. Bennett J. R. Smoking and the gastrointestinal tract. Gut. 1972 Aug;13(8):658–665. doi: 10.1136/gut.13.8.658. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. DOLL R., HILL A. B. Lung cancer and other causes of death in relation to smoking; a second report on the mortality of British doctors. Br Med J. 1956 Nov 10;2(5001):1071–1081. doi: 10.1136/bmj.2.5001.1071. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. DOLL R., HILL A. B. MORTALITY IN RELATION TO SMOKING: TEN YEARS' OBSERVATIONS OF BRITISH DOCTORS. Br Med J. 1964 Jun 6;1(5396):1460–CONCL. doi: 10.1136/bmj.1.5396.1460. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. DOLL R., JONES F. A., PYGOTT F. Effect of smoking on the production and maintenance of gastric and duodenal ulcers. Lancet. 1958 Mar 29;1(7022):657–662. doi: 10.1016/s0140-6736(58)91083-3. [DOI] [PubMed] [Google Scholar]
  6. DORN H. F. Tobacco consumption and mortality from cancer and other diseases. Public Health Rep. 1959 Jul;74(7):581–593. [PMC free article] [PubMed] [Google Scholar]
  7. DUNN J. E., Jr, LINDEN G., BRESLOW L. Lung cancer mortality experience of men in certain occupations in California. Am J Public Health Nations Health. 1960 Oct;50:1475–1487. doi: 10.2105/ajph.50.10.1475. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Doll R., Peto R. Mortality in relation to smoking: 20 years' observations on male British doctors. Br Med J. 1976 Dec 25;2(6051):1525–1536. doi: 10.1136/bmj.2.6051.1525. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. EDWARDS F., McKEOWN T., WHITFIELD A. G. Association between smoking and disease in men over sixty. Lancet. 1959 Jan 24;1(7065):196–200. doi: 10.1016/s0140-6736(59)90385-x. [DOI] [PubMed] [Google Scholar]
  10. Etherington D. J., Taylor W. H. The pepsins of normal human gastric juice. Biochem J. 1969 Jul;113(4):663–668. doi: 10.1042/bj1130663. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Fung W. P., Tye C. Y. Effect of smoking on gastric acid secretion. Aust N Z J Med. 1973 Jun;3(3):251–254. doi: 10.1111/j.1445-5994.1973.tb03090.x. [DOI] [PubMed] [Google Scholar]
  12. HAMMOND E. C., HORN D. Smoking and death rates; report on forty-four months of follow-up of 187,783 men. I. Total mortality. J Am Med Assoc. 1958 Mar 8;166(10):1159–1172. doi: 10.1001/jama.1958.02990100047009. [DOI] [PubMed] [Google Scholar]
  13. HAMMOND E. C. SMOKING IN RELATION TO MORTALITY AND MORBIDITY. FINDINGS IN FIRST THIRTY-FOUR MONTHS OF FOLLOW-UP IN A PROSPECTIVE STUDY STARTED IN 1959. J Natl Cancer Inst. 1964 May;32:1161–1188. [PubMed] [Google Scholar]
  14. Herrmann R. P., Piper D. W. Factors influencing the healing rate of chronic gastric ulcer. Am J Dig Dis. 1973 Jan;18(1):1–6. doi: 10.1007/BF01072230. [DOI] [PubMed] [Google Scholar]
  15. KAY A. W. Effect of large doses of histamine on gastric secretion of HCI; an augmented histamine test. Br Med J. 1953 Jul 11;2(4827):77–80. doi: 10.1136/bmj.2.4827.77. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. LILIENFELD A. M. Emotional and other selected characteristics of cigarette smokers and non-smokers as related to epidemiological studies of lung cancer and other diseases. J Natl Cancer Inst. 1959 Feb;22(2):259–282. [PubMed] [Google Scholar]
  17. MILLS C. A. Tobacco smoking: some hints of its biologic hazards. Ohio State Med J. 1950 Dec;46(12):1165–1170. [PubMed] [Google Scholar]
  18. Monson R. R. Cigarette smoking and body form in peptic ulcer. Gastroenterology. 1970 Mar;58(3):337–344. [PubMed] [Google Scholar]
  19. TOON R. W., CROSS F. S., WANGENSTEEN O. H. Effect of inhaled cigarette smoke on production of peptic ulcer in the dog. Proc Soc Exp Biol Med. 1951 Aug;77(4):866–869. doi: 10.3181/00379727-77-18951. [DOI] [PubMed] [Google Scholar]
  20. Taylor W. H. Pepsins of patients with peptic ulcer. Nature. 1970 Jul 4;227(5253):76–77. doi: 10.1038/227076a0. [DOI] [PubMed] [Google Scholar]
  21. Whitecross D. P., Clarke A. D., Piper D. W. The effect of cigarette smoking on human gastric secretion. Scand J Gastroenterol. 1974;9(4):399–403. [PubMed] [Google Scholar]

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