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. 1973 Jun;14(6):444–447. doi: 10.1136/gut.14.6.444

Asymptomatic primary biliary cirrhosis

R A Fox, P J Scheuer, Sheila Sherlock
PMCID: PMC1412729  PMID: 4719210

Abstract

Four asymptomatic patients are described with raised serum alkaline phosphatase values and a positive serum mitochondrial antibody test. In all four needle liver biopsy showed destructive bile duct lesions. Lymphocyte transformation to phytohaemagglutinin was normal in three and impaired in one who also suffered from rheumatoid arthritis. Two patients showed normal skin and serological test responses to dinitrochlorobenzene and haemocyanin.

These four patients are believed to be suffering from asymptomatic primary biliary cirrhosis.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Doniach D., Walker J. G. A unified concept of autoimmune hepatitis. Lancet. 1969 Apr 19;1(7599):813–815. doi: 10.1016/s0140-6736(69)92072-8. [DOI] [PubMed] [Google Scholar]
  2. Feizi T. Immunoglobulins in chronic liver disease. Gut. 1968 Apr;9(2):193–198. doi: 10.1136/gut.9.2.193. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. McKelvey E. M., Fahey J. L. Immunoglobulin changes in disease: quantitation on the basis of heavy polypeptide chains, IgG (gammaG), IgA (gammaA), and IgM (gammaM), and of light polypeptide chains, type K (I) and type L (II). J Clin Invest. 1965 Nov;44(11):1778–1787. doi: 10.1172/JCI105285. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. RUBIN E., SCHAFFNER F., POPPER H. PRIMARY BILIARY CIRRHOSIS. CHRONIC NON-SUPPURATIVE DESTRUCTIVE CHOLANGITIS. Am J Pathol. 1965 Mar;46:387–407. [PMC free article] [PubMed] [Google Scholar]
  5. SHERLOCK S. Primary billiary cirrhosis (chronic intrahepatic obstructive jaundice). Gastroenterology. 1959 Nov;37:574–586. [PubMed] [Google Scholar]
  6. Scheuer P. Primary biliary cirrhosis. Proc R Soc Med. 1967 Dec;60(12):1257–1260. doi: 10.1177/003591576706001205. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Sherlock S., Fox R. A., James D. G., Scheuer P. J., Sharma O. Impaired delayed hypersensitivity in primary biliary cirrhosis. Lancet. 1969 May 10;1(7602):959–962. doi: 10.1016/s0140-6736(69)91860-1. [DOI] [PubMed] [Google Scholar]
  8. Swanson M. A., Schwartz R. S. Immunosuppressive therapy. The relation between clinical response and immunologic competence. N Engl J Med. 1967 Jul 27;277(4):163–170. doi: 10.1056/NEJM196707272770401. [DOI] [PubMed] [Google Scholar]
  9. WALKER J. G., DONIACH D., ROITT I. M., SHERLOCK S. SEROLOGICAL TESTS IN DIAGNOSIS OF PRIMARY BILIARY CIRRHOSIS. Lancet. 1965 Apr 17;1(7390):827–831. doi: 10.1016/s0140-6736(65)91372-3. [DOI] [PubMed] [Google Scholar]
  10. Walker J. G., Doniach D., Doniach I. Mitochondrial antibodies and subclinical liver disease. Q J Med. 1970 Jan;39(153):31–48. [PubMed] [Google Scholar]
  11. Zeegen R., Stansfeld A. G., Dawson A. M., Hunt A. H. Bleeding oesophageal varices as the presenting feature in primary bilirary cirrhosis. Lancet. 1969 Jul 5;2(7610):9–12. doi: 10.1016/s0140-6736(69)92595-1. [DOI] [PubMed] [Google Scholar]

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