Skip to main content
PMC home page
Gut logoLink to Gut
. 1973 Jul;14(7):545–548. doi: 10.1136/gut.14.7.545

Studies of carcinoembryonic antigen of whole and extracted serum in ulcerative colitis

S K Khoo, P S Hunt, I R Mackay
PMCID: PMC1412801  PMID: 4354145

Abstract

The present study has used a microradioimmunoassay to detect carcinoembryonic antigen(s) (CEA) in whole and extracted serum in 77 patients with ulcerative colitis, two of whom had coexisting colonic carcinoma, and 69 patients with carcinoma of the colon or rectum. Taking 5 ng/ml as the level of positivity, the CEA assay on whole serum showed positive results in patients with `active' ulcerative colitis (15 of 17) but not in those with `inactive' disease (0 of 23). In two patients, levels fell during drug-induced remission. Our results also indicated that a positive result for CEA on extracted serum was associated with carcinomatous changes in ulcerative colitis in contrast to uncomplicated ulcerative colitis in which positive results were obtained only with whole serum.

Full text

PDF
545

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Brooke B. N. Ulcerative colitis and carcinoma of the colon. J R Coll Surg Edinb. 1969 Sep;14(5):274–278. [PubMed] [Google Scholar]
  2. Burdette W. J. Identification of antecedents to colorectal cancer. Cancer. 1971 Jul;28(1):51–59. doi: 10.1002/1097-0142(197107)28:1<51::aid-cncr2820280112>3.0.co;2-v. [DOI] [PubMed] [Google Scholar]
  3. COUNSELL P. B., DUKES C. E. The association of chronic ulcerative colitis and carcinoma of the rectum and colon. Br J Surg. 1952 May;39(158):485–495. doi: 10.1002/bjs.18003915803. [DOI] [PubMed] [Google Scholar]
  4. Chu T. M., Reynoso G., Hansen H. J. Demonstration of carcinoembryonic antigen in normal human plasma. Nature. 1972 Jul 21;238(5360):152–153. doi: 10.1038/238152a0. [DOI] [PubMed] [Google Scholar]
  5. Freed D. L., Taylor G. Carcinoembryonic antigen in faeces. Br Med J. 1972 Jan 8;1(5792):85–87. doi: 10.1136/bmj.1.5792.85. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Hinton J. M. Risk of malignant change in ulcerative colitis. Gut. 1966 Oct;7(5):427–432. doi: 10.1136/gut.7.5.427. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Kronman B. S. Ulcerative colitis, autoimmune epiphenomena, and colonic cancer. Cancer. 1971 Jul;28(1):82–88. doi: 10.1002/1097-0142(197107)28:1<82::aid-cncr2820280116>3.0.co;2-d. [DOI] [PubMed] [Google Scholar]
  8. LeBel J. S., Deodhar S. D., Brown C. H. Evaluation of a radioimmunoassay for carcinoembryonic antigen of the human digestive system. Cleve Clin Q. 1972 Spring;39(1):25–31. doi: 10.3949/ccjm.39.1.25. [DOI] [PubMed] [Google Scholar]
  9. Lo Gerfo P., Krupey J., Hansen H. J. Demonstration of an antigen common to several varieties of neoplasia. N Engl J Med. 1971 Jul 15;285(3):138–141. doi: 10.1056/NEJM197107152850302. [DOI] [PubMed] [Google Scholar]
  10. Lo Gerfo P., Lo Gerfo F., Herter F., Barker H. G., Hansen H. J. Tumor-associated antigen in patients with carcinoma of the colon. Am J Surg. 1972 Feb;123(2):127–131. doi: 10.1016/0002-9610(72)90321-2. [DOI] [PubMed] [Google Scholar]
  11. MacSween J. M., Warner N. L., Bankhurst A. D., Mackay I. R. Carcinoembryonic antigen in whole serum. Br J Cancer. 1972 Oct;26(5):356–360. doi: 10.1038/bjc.1972.46. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. MacSween J. M., Warner N. L., Mackay I. R. The detection of carcinoembryonic antigen in whole serum from patients with malignant and nonmalignant disease. Clin Immunol Immunopathol. 1973 Apr;1(3):330–345. doi: 10.1016/0090-1229(73)90050-0. [DOI] [PubMed] [Google Scholar]
  13. Martin F., Martin M. S. Radioimmunoassay of carcinoembryonic antigen in extracts of human colon and stomach. Int J Cancer. 1972 May 15;9(3):641–647. doi: 10.1002/ijc.2910090322. [DOI] [PubMed] [Google Scholar]
  14. Moore T. L., Kantrowitz P. A., Zamcheck N. Carcinoembryonic antigen (CEA) in inflammatory bowel disease. JAMA. 1972 Nov 20;222(8):944–947. [PubMed] [Google Scholar]
  15. Rule A. H., Straus E., Vandevoorde J., Janowitz H. D. Tumor-associated (CEA-reacting) antigen in patients with inflammatory bowel disease. N Engl J Med. 1972 Jul 6;287(1):24–26. doi: 10.1056/NEJM197207062870106. [DOI] [PubMed] [Google Scholar]
  16. Thomson D. M., Krupey J., Freedman S. O., Gold P. The radioimmunoassay of circulating carcinoembryonic antigen of the human digestive system. Proc Natl Acad Sci U S A. 1969 Sep;64(1):161–167. doi: 10.1073/pnas.64.1.161. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Zamcheck N., Moore T. L., Dhar P., Kupchik H. Immunologic diagnosis and prognosis of human digestive-tract cancer: carcinoembryonic antigens. N Engl J Med. 1972 Jan 13;286(2):83–86. doi: 10.1056/NEJM197201132860207. [DOI] [PubMed] [Google Scholar]

Articles from Gut are provided here courtesy of BMJ Publishing Group

RESOURCES