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. 1979 Dec;20(12):1072–1077. doi: 10.1136/gut.20.12.1072

Bile acid studies in patients with Crohn's colitis.

P Rutgeerts, Y Ghoos, G Vantrappen
PMCID: PMC1412836  PMID: 527881

Abstract

Bile acid studies were performed in patients with Crohn's disease, radiologically confined to the colon. The bile acid pool size of 10 patients with isolated Crohn's colitis was significantly lower than that of 10 normal control subjects (P less than 0.001) and of 10 ulcerative colitis patients (P less than 0.005). Measurements of 14C-excretion in breath and in 24 hours stool collections after the administration of 5 muCi 14C-glycocholate showed a normal 14C-excretion in breath and usually a markedly increased loss of 14C in the stool (greater than 7% of the dose). The simultaneous administration of 5 muCi 3H-polyethylene glycol MW 4000 (3H-PEG) as a marker indicated that the 14C/3H ratio in the patients with Crohn's colitis was significantly greater than in a control series of patients with diarrhoea not due to bile acid malabsorption. Studies on the composition of duodenal bile showed a significantly decreased concentration of deoxycholic acid in duodenal bile. These observations suggest bile acid malabsorption in patients with Crohn's disease apparently confined to the colon.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Best W. R., Becktel J. M., Singleton J. W., Kern F., Jr Development of a Crohn's disease activity index. National Cooperative Crohn's Disease Study. Gastroenterology. 1976 Mar;70(3):439–444. [PubMed] [Google Scholar]
  2. Einarsson K., Hellström K., Kallner M. Bile acid kinetics in relation to sex, serum lipids, body weights, and gallbladder disease in patients with various types of hyperlipoproteinemia;. J Clin Invest. 1974 Dec;54(6):1301–1311. doi: 10.1172/JCI107876. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Fromm H., Hofmann A. F. Breath test for altered bile-acid metabolism. Lancet. 1971 Sep 18;2(7725):621–625. doi: 10.1016/s0140-6736(71)80068-5. [DOI] [PubMed] [Google Scholar]
  4. Fromm H., Thomas P. J., Hofmann A. F. Sensitivity and specificity in tests of distal ileal function: prospective comparison of bile acid and vitamin B 12 absorption in ileal resection patients. Gastroenterology. 1973 Jun;64(6):1077–1090. [PubMed] [Google Scholar]
  5. Ghoos Y., Vantrappen G. Clean collection and manipulation of stools. Lancet. 1977 Apr 23;1(8017):884–885. doi: 10.1016/s0140-6736(77)91204-1. [DOI] [PubMed] [Google Scholar]
  6. Heaton K. W. Disturbances of bile acid metabolism in intestinal disease. Clin Gastroenterol. 1977 Jan;6(1):69–89. [PubMed] [Google Scholar]
  7. Hepner G. W. Increased sensitivity of the cholylglycine breath test for detecting ileal dysfunction. Gastroenterology. 1975 Jan;68(1):8–16. [PubMed] [Google Scholar]
  8. Jeejeebhoy K. N., Ahmad S., Kozak G. Determination of fecal fats containing both medium and long chain triglycerides and fatty acids. Clin Biochem. 1970 Jun;3(2):157–163. [PubMed] [Google Scholar]
  9. Kern F., Jr Disappearance of deoxycholic acid after ileal resection. Gastroenterology. 1973 Jan;64(1):123–127. [PubMed] [Google Scholar]
  10. Lenz K. An evaluation of the 'breath test' in Crohn's disease. Scand J Gastroenterol. 1975;10(6):665–671. [PubMed] [Google Scholar]
  11. Lenz K. Bile acid metabolism and vitamin B12 absorption in ulcerative colitis. Scand J Gastroenterol. 1976;11(8):769–775. [PubMed] [Google Scholar]
  12. Pomare E. W., Low-Beer T. S. Measurement and validation of human bile salt pool size and synthesis. Clin Chim Acta. 1974 Dec 17;57(3):239–248. doi: 10.1016/0009-8981(74)90403-3. [DOI] [PubMed] [Google Scholar]
  13. Scarpello J. H., Sladen G. E. 14C-Glycocholate test in Crohn's disease--its value in assessment and treatment. Gut. 1977 Sep;18(9):736–741. doi: 10.1136/gut.18.9.736. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Thaysen E. H., Bruusgaard A., Eriksen B. Evaluation of the efficiency of bile salt recirculation in patients with terminal ileopathies by means of deoxycholate determination in duodenal aspirates. Scand J Gastroenterol. 1970;5(1):39–47. [PubMed] [Google Scholar]
  15. Vantrappen G., Ghoos Y., Rutgeerts P., Janssens J. Bile acid studies in uncomplicated Crohn's disease. Gut. 1977 Sep;18(9):730–735. doi: 10.1136/gut.18.9.730. [DOI] [PMC free article] [PubMed] [Google Scholar]

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