Abstract
Basal, as well as betazole-stimulated gastric acid secretion in man is reduced after the intravenous administration of bromazepam. In subjects staying awake, this reduction is limited to the first two 15-minute periods. The reduction is highly significant in subjects who fall asleep after receiving the drug. Natural sleep causes the same depression. The low level of acid secretion is maintained until the subjects are awakened when there is a sharp and highly significant rise. Acid secretion in subjects who fall asleep after the simultaneous administration of betazole and bromazepam is significantly higher than after the administration of bromazepam alone. Sleep causes a much greater depression of basal and betazole-stimulated acid secretion than does the benzodiazepine itself.
Acid secretion was measured by continuous intragastric titration and a pH-sensitive endoradiosonde.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Berner P., Neumayr A., Stacher G. Angst und Magensäureproduktion. Z Gastroenterol. 1971;9(4):256–265. [PubMed] [Google Scholar]
- Birnbaum D., Karmeli F., Tefera M. The effect of diazepam on human gastric secretion. Gut. 1971 Aug;12(8):616–618. doi: 10.1136/gut.12.8.616. [DOI] [PMC free article] [PubMed] [Google Scholar]
- ENGEL G. L., REICHSMAN F., SEGAL H. L. A study of an infant with a gastric fistula. I. Behavior and the rate of total hydrochloric acid secretion. Psychosom Med. 1956 Sep-Oct;18(5):374–398. doi: 10.1097/00006842-195609000-00002. [DOI] [PubMed] [Google Scholar]
- MARKS I. N., KOMAROV S. A., SHAY H. Acid secretory responses to histamine and the parietal cell mass in the dog. Am J Physiol. 1958 Nov;195(2):528–534. doi: 10.1152/ajplegacy.1958.195.2.528. [DOI] [PubMed] [Google Scholar]
- Powell D. W., Hirschowitz B. I. Sodium pentobarbital depression of histamine- or insulin-stimulated gastric secretion. Am J Physiol. 1967 May;212(5):1001–1006. doi: 10.1152/ajplegacy.1967.212.5.1001. [DOI] [PubMed] [Google Scholar]
- REICHSMAN F., COHEN J., COLWILL J., DAVIS N., KESSLER W., SHEPARDSON C. R., ENGEL G. L. Natural and histamine-induced gastric secretion during waking and sleeping states. Psychosom Med. 1960 Jan-Feb;22:14–23. doi: 10.1097/00006842-196001000-00003. [DOI] [PubMed] [Google Scholar]
- Stacher G. Zur Frage der Magensäuresekretion im Schlaf. Wien Klin Wochenschr. 1973 Oct 19;85(42):702–706. [PubMed] [Google Scholar]
- Stavney L. S., Hamilton T., Sircus W., Smith A. N. Evaluation of the pH-sensitive telemetering capsule in the estimation of gastric secretory capacity. Am J Dig Dis. 1966 Oct;11(10):753–760. doi: 10.1007/BF02233835. [DOI] [PubMed] [Google Scholar]