Skip to main content
NCBI home page
Gut logoLink to Gut
. 1974 Aug;15(8):622–625. doi: 10.1136/gut.15.8.622

The effect of calcium on gastric acid and gastrin secretion in antrectomized subjects

J Christiansen, J F Rehfeld, F Stadil
PMCID: PMC1413022  PMID: 4419523

Abstract

Serum gastrin concentrations and gastric acid secretion were measured in nine antrectomized subjects during infusion of saline and calcium gluconate. The basal gastrin level was of the same magnitude as in normal individuals and unoperated duodenal ulcer patients. Calcium infusion only induced gastrin release in one patient and did not induce acid secretion in any of the patients.

Full text

PDF
622

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Barreras R. F., Donaldson R. M., Jr Effects of induced hypercalcemia on human gastric secretion. Gastroenterology. 1967 Apr;52(4):670–675. [PubMed] [Google Scholar]
  2. Basso N., Passaro E., Jr Calcium-stimulated gastric secretion in the Zollinger-Ellison syndrome. Arch Surg. 1970 Sep;101(3):399–402. doi: 10.1001/archsurg.1970.01340270047013. [DOI] [PubMed] [Google Scholar]
  3. Christiansen J., Aagaard P. Parathyroid adenoma and gastric acid secretion. Scand J Gastroenterol. 1972;7(5):445–449. doi: 10.3109/00365527209180768. [DOI] [PubMed] [Google Scholar]
  4. Christiansen J., Hendel L. Interaction of calcium and pentagastrin on gastric acid secretion in man. Gut. 1972 Aug;13(8):643–645. doi: 10.1136/gut.13.8.643. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Dent R. I., James J. H., Want C. A., Deftos L. J., Talamo R., Fischer J. E. Hyperparathyroidism: gastric acid secretion and gastrin. Ann Surg. 1972 Sep;176(3):360–369. doi: 10.1097/00000658-197209000-00012. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Murphy D. L., Goldstein H., Boyle J. D., Ward S. Hypercalcemia and gastric secretion in man. J Appl Physiol. 1966 Sep;21(5):1607–1610. doi: 10.1152/jappl.1966.21.5.1607. [DOI] [PubMed] [Google Scholar]
  7. Reeder D. D., Jackson B. M., Ban J., Clendinnen B. G., Davidson W. D., Thompson J. C. Influence of hypercalcemia on gastric secretion and serum gastrin concentrations in man. Ann Surg. 1970 Oct;172(4):540–546. doi: 10.1097/00000658-197010000-00002. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Rehfeld J. F. Gastrins in serum. A review of gastrin radioimmunoanalysis and the discovery of gastrin heterogeneity in serum. Scand J Gastroenterol. 1973;8(7):577–583. [PubMed] [Google Scholar]
  9. Rehfeld J. F., Stadil F., Rubin B. Production and evaluation of antibodies for the radioimmunoassay of gastrin. Scand J Clin Lab Invest. 1972 Oct;30(2):221–232. doi: 10.3109/00365517209081114. [DOI] [PubMed] [Google Scholar]
  10. Rehfeld J. F., Stadil F., Vikelsoe J. Immunoreactive gastrin components in human serum. Gut. 1974 Feb;15(2):102–111. doi: 10.1136/gut.15.2.102. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Rosato E. F., Mullen J. L., Lanciault G., Rosato F. E., Brooks F. P. The dissociation of gastric acid output and plasma gastrin concentration after calcium infusions in conscious monkeys. Surgery. 1973 Feb;73(2):207–211. [PubMed] [Google Scholar]
  12. Smallwood R. A. Effect of intravenous calcium administration on gastric secretion of acid and pepsin in man. Gut. 1967 Dec;8(6):592–598. doi: 10.1136/gut.8.6.592. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Stadil F., Rehfeld J. F. Determination of gastrin in serum. An evaluation of the reliability of a radioimmunoassay. Scand J Gastroenterol. 1973;8(2):101–112. [PubMed] [Google Scholar]
  14. Stadil F., Rehfeld J. F. Preparation of 125 I-labelled synthetic human gastrin I for radioimmunoanalysis. Scand J Clin Lab Invest. 1972 Dec;30(4):361–368. doi: 10.3109/00365517209080271. [DOI] [PubMed] [Google Scholar]
  15. Stadil F., Rehfeld J. F. Radioimmunoassay of gastrin in human serum. Scand J Gastroenterol Suppl. 1971;9:61–65. [PubMed] [Google Scholar]
  16. Stern D. H., Walsh J. H. Gastrin release in postoperative ulcer patients: evidence for release of duodenal gastrin. Gastroenterology. 1973 Mar;64(3):363–369. [PubMed] [Google Scholar]
  17. Sutherland E. W., Robison G. A. The role of cyclic-3',5'-AMP in responses to catecholamines and other hormones. Pharmacol Rev. 1966 Mar;18(1):145–161. [PubMed] [Google Scholar]
  18. Trudeau W. L., McGuigan J. E. Effects of calcium on serum gastrin levels in the zollinger-Ellison syndrome. N Engl J Med. 1969 Oct 16;281(16):862–866. doi: 10.1056/NEJM196910162811602. [DOI] [PubMed] [Google Scholar]

Articles from Gut are provided here courtesy of BMJ Publishing Group

RESOURCES