Skip to main content
NCBI home page
Gut logoLink to Gut
. 1974 Sep;15(9):728–732. doi: 10.1136/gut.15.9.728

Luminal distension as a possible consequence of experimental intestinal perfusion

David Wingate, Ashley Hyams, Sidney Phillips
PMCID: PMC1413035  PMID: 4435588

Abstract

In an experimental jejunal perfusion study, distress in healthy subjects occurred during eight out of 16 perfusions in which intestinal secretion was provoked. Calculation demonstrates the volumetric consequences of inadequate recovery of secretory perfusates, and analysis of the perfusion studies shows that distress was significantly associated with poor recovery of the perfusate. These observations are pertinent to increasing interest in the phenomenon of intestinal fluid secretion.

Full text

PDF
728

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Fordtran J. S. Segmental perfusion techniques. Gastroenterology. 1969 May;56(5):987–989. [PubMed] [Google Scholar]
  2. Hepner G. W., Hofmann A. F. Different effects of free and conjugated bile acids and their keto derivatives on (Na + ,K + )-stimulated and Mg 2 +ATPase of rat intestinal mucosa. Biochim Biophys Acta. 1973 Jan 2;291(1):237–245. doi: 10.1016/0005-2736(73)90415-x. [DOI] [PubMed] [Google Scholar]
  3. Modigliani R., Bernier J. J. Absorption of glucose, sodium, and water by the human jejunum studied by intestinal perfusion with a proximal occluding balloon and at variable flow rates. Gut. 1971 Mar;12(3):184–193. doi: 10.1136/gut.12.3.184. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Phillips S. F., Summerskill W. H. Occlusion of the jejunum for intestinal perfusion in man. Mayo Clin Proc. 1966 Apr;41(4):224–231. [PubMed] [Google Scholar]
  5. Russell R. I., Allan J. G., Gerskowitch V. P., Cochran K. M. The effect of conjugated and unconjugated bile acids on water and electrolyte absorption in the human jejunum. Clin Sci Mol Med. 1973 Sep;45(3):301–311. doi: 10.1042/cs0450301. [DOI] [PubMed] [Google Scholar]
  6. Schmid W. C., Phillips S. F., Summerskill W. H. Jejunal trauma following perfusion of the small intestine in nontropical sprue. Gastroenterology. 1968 Mar;54(3):417–420. [PubMed] [Google Scholar]
  7. Sladen G. E., Dawson A. M. An evaluation of perfusion techniques in the study of water and electrolyte absorption in man: the problem of endogenous secretions. Gut. 1968 Oct;9(5):530–535. doi: 10.1136/gut.9.5.530. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Sladen G. E., Dawson A. M. Further studies on the perfusion method for measuring intestinal absorption in man: the effects of a proximal occlusive balloon and a mixing segment. Gut. 1970 Nov;11(11):947–954. doi: 10.1136/gut.11.11.947. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Whalen G. E., Harris J. A., Geenen J. E., Soergel K. H. Sodium and water absorption from the human small intestine. The accuracy of the perfusion method. Gastroenterology. 1966 Dec;51(6):975–984. [PubMed] [Google Scholar]
  10. Wingate D. L., Phillips S. F., Hofmann A. F. Effect of glycine-conjugated bile acids with and without lecithin on water and glucose absorption in perfused human jejunum. J Clin Invest. 1973 May;52(5):1230–1236. doi: 10.1172/JCI107290. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Wingate D. L., Sandberg R. J., Phillips S. F. A comparison of stable and 14 C-labelled polyethylene glycol as volume indicators in the human jejunum. Gut. 1972 Oct;13(10):812–815. doi: 10.1136/gut.13.10.812. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from Gut are provided here courtesy of BMJ Publishing Group

RESOURCES