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. 1974 Sep;15(9):706–709. doi: 10.1136/gut.15.9.706

Supersensitivity to pentagastrin in diffuse oesophageal spasm

V Eckardt, H Weigand
PMCID: PMC1413045  PMID: 4215703

Abstract

A 38-year-old patient, complaining of dysphagia and substernal pain of nine months' duration, was found by manometric studies to have diffuse oesophageal spasm. As has similarly been reported for cholinergic agents in achalasia and in some cases of diffuse oesophageal spasm the oesophageal body responded in a hypersensitive fashion to subcutaneous and intravenous injections of pentagastrin. This effect was inhibited by the intravenous administration of atropine and completely abolished by nitroglycerine. When pentagastrin was subcutaneously injected before a barium examination a distortion of the oesophageal contour, described as curling or corkscrew oesophagus, regularly appeared.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bennett A. Effect of gastrin on isolated smooth muscle preparation. Nature. 1965 Oct 9;208(5006):170–173. doi: 10.1038/208170a0. [DOI] [PubMed] [Google Scholar]
  2. Castell D. O., Levine S. M. Lower esophageal sphincter response to gastric alkalinization. A new mechanism for treatment of heartburn with antacids. Ann Intern Med. 1971 Feb;74(2):223–227. doi: 10.7326/0003-4819-74-2-223. [DOI] [PubMed] [Google Scholar]
  3. Cohen S., Lipshutz W., Hughes W. Role of gastrin supersensitivity in the pathogenesis of lower esophageal sphincter hypertension in achalasia. J Clin Invest. 1971 Jun;50(6):1241–1247. doi: 10.1172/JCI106601. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Fleshler B. Diffuse esophageal spasm. Gastroenterology. 1967 Mar;52(3):559–564. [PubMed] [Google Scholar]
  5. Giles G. R., Mason M. C., Humphries C., Clark C. G. Action of gastrin on the lower oesophageal sphincter in man. Gut. 1969 Sep;10(9):730–734. doi: 10.1136/gut.10.9.730. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Gillies M., Nicks R., Skyring A. Clinical, manometric, and pathological studies in diffuse oesophageal spasm. Br Med J. 1967 May 27;2(5551):527–530. doi: 10.1136/bmj.2.5551.527. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Kramer P., Fleshler B., McNally E., Harris L. D. Oesophageal sensitivity to Mecholyl in symptomatic diffuse spasm. Gut. 1967 Apr;8(2):120–127. doi: 10.1136/gut.8.2.120. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Orlando R. C., Bozymski E. M. Clinical and manometric effects of nitroglycerin in diffuse esophageal spasm. N Engl J Med. 1973 Jul 5;289(1):23–25. doi: 10.1056/NEJM197307052890106. [DOI] [PubMed] [Google Scholar]
  9. ROTH H. P., FLESHLER B. DIFFUSE ESOPHAGEAL SPASM; CLINICAL, RADIOLOGICAL, AND MANOMETRIC OBSERVATIONS. Ann Intern Med. 1964 Nov;61:914–923. doi: 10.7326/0003-4819-61-5-914. [DOI] [PubMed] [Google Scholar]

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