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. 1975 Oct;16(10):776–773. doi: 10.1136/gut.16.10.776

Gastrin response to meals of different composition in normal subjects.

E L Blair, J R Greenwell, E R Grund, J D Reed, D J Sanders
PMCID: PMC1413094  PMID: 1205269

Abstract

The serum gastrin responses and the integrated gastrin responses to eating three meals of very different composition were studied in the same normal subjects on different days. Two meals, a milk meal of 500 ml, and a breakfast of eggs, toast, butter, marmalade, fruit juice and coffee, were eaten at breakfast time. The serum gastrin responses to these meals were compared and contrasted with the concentrations observed when the subjects fasted over the same time of day. A steak meal was eaten at lunch time. There were no significant differences between the mean serum gastrin concentrations to the three meals but each meal produced a significant increase in serum gastrin above fasting levels. When the prefeeding gastrin concentration was subtracted from the gastrin responses then the integrated responses to the steak meal were greater than those to either of the breakfast meals. Considerable variability in response to any one meal was observed within the group of subjects, but those subjects who produced high serum gastrin concentrations to one meal did so to the others. Conversely, at low response to one meal was reflected in low responses to the other two meals. Fasting serum gastrin concentration was correlated with the age of the subject. Repeatability of the response to one meal was tested in two subjects who ate the same meal on four separate occasions showing their responses to be repeatable.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Becker H. D., Reeder D. D., Thompson J. C. Effect of truncal vagotomy with pyloroplasty or with antrectomy on food-stimulated gastrin values in patients with duodenal ulcer. Surgery. 1973 Oct;74(4):580–586. [PubMed] [Google Scholar]
  2. Blair E. L., Grund E. R., Lund P. K., Reed J. D., Sanders D. J. Immunoreactive gastrin variants in cat serum. J Physiol. 1975 May;247(1):33P–34P. [PubMed] [Google Scholar]
  3. Bunchman H. H., 2nd, Reeder D. D., Thompson J. C. Effect of secretin on the serum gastrin response to a meal in man and in dog. Surg Forum. 1971;22:303–304. [PubMed] [Google Scholar]
  4. Byrnes D. J., Young J. D., Chisholm D. J., Lazarus L. Serum gastrin in patients with peptic ulceration. Br Med J. 1970 Jun 13;2(5710):626–629. doi: 10.1136/bmj.2.5710.626. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Debas H. T., Walsh J. H., Grossman M. I. Pure human minigastrin: secretory potency and disappearance rate. Gut. 1974 Sep;15(9):686–689. doi: 10.1136/gut.15.9.686. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Ganguli P. C., Forrester J. M. Circadian rhythm in plasma level of gastrin. Nat New Biol. 1972 Mar 29;236(65):127–128. doi: 10.1038/newbio236127a0. [DOI] [PubMed] [Google Scholar]
  7. Ganguli P. C., Hunter W. M. Radio-immunoassay of gastrin in human plasma. J Physiol. 1972 Jan;220(2):499–510. [PMC free article] [PubMed] [Google Scholar]
  8. Gedde-Dahl D. Radioimmunoassay of gastrin. Fasting serum levels in humans with normal and high gastric acid secreation. Scand J Gastroenterol. 1974;9(1):41–47. [PubMed] [Google Scholar]
  9. Hansky J., Soveny C., Korman M. G. Studies with two gastrin antisera of different specificity for gastrins I and II. Digestion. 1974;10(2):97–107. doi: 10.1159/000197528. [DOI] [PubMed] [Google Scholar]
  10. Hansky J., Soveny C., Korman M. G. Value of serum gastrin in the diagnosis of the Zollinger-Ellison syndrome. Aust N Z J Med. 1973 Aug;3(4):349–354. doi: 10.1111/j.1445-5994.1973.tb03105.x. [DOI] [PubMed] [Google Scholar]
  11. Isenberg J. I., Walsh J. H., Passaro E., Jr, Moore E. W., Grossman M. I. Unusual effect of secretin on serum gastrin, serum calcium, and gastric acid secretion in a patient with suspected Zollinger-Ellison syndrome. Gastroenterology. 1972 Apr;62(4):626–631. [PubMed] [Google Scholar]
  12. Korman M. G., Soveny C., Hansky J. Effect of food on serum gastrin evaluated by radioimmunoassay. Gut. 1971 Aug;12(8):619–624. doi: 10.1136/gut.12.8.619. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Maxwell J. G., Moore J. G., Dixon J., Stevens L. E. Gastrin levels in anephric patients. Surg Forum. 1971;22:305–306. [PubMed] [Google Scholar]
  14. McGuigan J. E. Immunochemical studies with synthetic human gastrin. Gastroenterology. 1968 Jun;54(6):1005–1011. [PubMed] [Google Scholar]
  15. McGuigan J. E., Trudeau W. L. Differences in rates of gastrin release in normal persons and patients with duodenal-ulcer disease. N Engl J Med. 1973 Jan 11;288(2):64–66. doi: 10.1056/NEJM197301112880202. [DOI] [PubMed] [Google Scholar]
  16. McGuigan J. E., Trudeau W. L. Serum gastrin concentrations in pernicious anemia. N Engl J Med. 1970 Feb 12;282(7):358–361. doi: 10.1056/NEJM197002122820703. [DOI] [PubMed] [Google Scholar]
  17. Moore J. G., Wolfe M. The relation of plasma gastrin to the circadian rhythm of gastric acid secretion in man. Digestion. 1973;9(2):97–105. doi: 10.1159/000197435. [DOI] [PubMed] [Google Scholar]
  18. Müller J., Fritsch W. P., Rick W., Hausamen T. U. Die radioimmunologische Serumgastrinbestimmung. Med Welt. 1973 Jun 15;24(24):1017–1018. [PubMed] [Google Scholar]
  19. Reeder D. D., Jackson B. M., Ban J. L., Davidson W. D., Thompson J. C. Effect of food on serum gastrin concentrations in duodenal ulcer and control patients. Surg Forum. 1970;21:290–291. [PubMed] [Google Scholar]
  20. Schrumpf E., Sand T. Radioimmunoassay of gastrin with activated charcoal. Scand J Gastroenterol. 1972;7(8):683–687. doi: 10.3109/00365527209180977. [DOI] [PubMed] [Google Scholar]
  21. Stadil F., Rehfeld J. F. Determination of gastrin in serum. An evaluation of the reliability of a radioimmunoassay. Scand J Gastroenterol. 1973;8(2):101–112. [PubMed] [Google Scholar]
  22. Stadil F., Rehfeld J. F. Preparation of 125 I-labelled synthetic human gastrin I for radioimmunoanalysis. Scand J Clin Lab Invest. 1972 Dec;30(4):361–368. doi: 10.3109/00365517209080271. [DOI] [PubMed] [Google Scholar]
  23. Stern D. H., Walsh J. H. Gastrin release in postoperative ulcer patients: evidence for release of duodenal gastrin. Gastroenterology. 1973 Mar;64(3):363–369. [PubMed] [Google Scholar]
  24. Thein M. P., Schofield B. Release of gastrin from the pyloric antrum following vagal stimulation by sham feeding in dogs. J Physiol. 1959 Oct;148(2):291–305. doi: 10.1113/jphysiol.1959.sp006289. [DOI] [PMC free article] [PubMed] [Google Scholar]
  25. Trudeau W. L., McGuigan J. E. Relations between serum gastrin levels and rates of gastric hydrochloric acid secretion. N Engl J Med. 1971 Feb 25;284(8):408–412. doi: 10.1056/NEJM197102252840803. [DOI] [PubMed] [Google Scholar]
  26. Wyllie J. H., Boulos P. B., Lewin M. R., Stagg B. H., Clark C. G. Plasma gastrin and acid secretion in man following stimulation by food, meat extract, and insulin. Gut. 1972 Nov;13(11):887–893. doi: 10.1136/gut.13.11.887. [DOI] [PMC free article] [PubMed] [Google Scholar]
  27. Yalow R. S., Berson S. A. Radioimmunoassay of gastrin. Gastroenterology. 1970 Jan;58(1):1–14. [PubMed] [Google Scholar]

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