Abstract
The numbers of mast cells and of IgE-containing immunocytes in the bowel wall of patients suffering from Crohn's disease of ulcerative colitis have been estimated and the results compared with those found in normal control specimens. In ulcerative colitis there is a slight rise in the number of mast cells and it appears that these participate in the inflammatory process in a non-specific manner; the number of IgE-containing immunocytes is not significantly altered. In Crohn's disease there is an almost total absence of stainable mast cells in affected areas of the bowel, together with a marked decrease in IgE-containing immunocytes. It is suggested that these findings are due to degranulation of mast cells and consumption of IgE as a result of an immediate hypersensitivity reaction in the bowel wall, this being one component of the protein inflammatory and immunological response to the entry of a variety of antigenic material.
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Selected References
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- Bercovitz Z. T., Sommers S. C. Altered inflammatory reaction in nonspecific ulcerative colitis. Arch Intern Med. 1966 Apr;117(4):504–510. [PubMed] [Google Scholar]
- Cook M. G., Turnbull G. J. A hypothesis for the pathogenesis of Crohn's disease based on an ultrastructural study. Virchows Arch A Pathol Anat Histol. 1975;365(4):327–336. doi: 10.1007/BF00471180. [DOI] [PubMed] [Google Scholar]
- Green F. H., Fox H. The distribution of mucosal antibodies in the bowel of patients with Crohn's disease. Gut. 1975 Feb;16(2):125–131. doi: 10.1136/gut.16.2.125. [DOI] [PMC free article] [PubMed] [Google Scholar]
- HIATT R. B., KATZ L. Mast cells in inflammatory conditions of the gastrointestinal tract. Am J Gastroenterol. 1962 May;37:541–545. [PubMed] [Google Scholar]
- MCGOVERN V. J., ARCHER G. T. The pathogenesis of ulcerative colitis. Australas Ann Med. 1957 Feb;6(1):68–74. doi: 10.1111/imj.1957.6.1.68. [DOI] [PubMed] [Google Scholar]
- Murray M., Jarrett W. F., Jennings F. W. Mast cells and macromolecular leak in intestinal immunological reactions. The influence of sex of rats infected with Nippostrongylus brasiliensis. Immunology. 1971 Jul;21(1):17–31. [PMC free article] [PubMed] [Google Scholar]
- Ranlöv P., Nielsen M. H., Wanstrup J. Ultrastructure of the ileum in Crohn's disease. Immune lesions and mastocytosis. Scand J Gastroenterol. 1972;7(5):471–476. doi: 10.3109/00365527209180772. [DOI] [PubMed] [Google Scholar]
- Rao S. N. Mast cells as a component of the granuloma in Crohn's disease. J Pathol. 1973 Jan;109(1):79–82. doi: 10.1002/path.1711090109. [DOI] [PubMed] [Google Scholar]
- Sommers S. C. Mast cells and paneth cells in ulcerative colitis. Gastroenterology. 1966 Nov;51(5):841–850. [PubMed] [Google Scholar]
- Stanworth D. R. Immunoglobulin E (reagin) and allergy. Nature. 1971 Oct 1;233(5318):310–316. doi: 10.1038/233310a0. [DOI] [PubMed] [Google Scholar]