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. 1975 Nov;16(11):847–853. doi: 10.1136/gut.16.11.847

Peripheral blood and intestinal lymphocyte sub-populations in Crohn's disease.

R G Strickland, G Husby, W C Black, R C Williams Jr
PMCID: PMC1413132  PMID: 1081463

Abstract

Immunofluorescent technques were utilized to study the nature and distribution of cells forming the inflammatory infiltrate in Crohn's disease. Tissue from resected ileum (one patient) or colon (one patient) when compared with corresponding control tissues contained increased numbers of B and T lymphocytes. B-cells of IgG class predominated in the mucosal lamina propria, whereas T-cells were prominent in the deeper layers of inflamed bowel. Inflammatory cells bearing Fc receptors were also present in these tissues. Decreased peripheral blood T-cell numbers returned to normal after resection of the involved bowel in the two patients studied. Impaired cellular immunity in Crohn's disease may thus result from T-cell sequestration in or loss from involved segments of intestine.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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