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. 1961 Jun;2(2):141–149. doi: 10.1136/gut.2.2.141

Iron deficiency after partial gastrectomy

J R Hobbs
PMCID: PMC1413249  PMID: 13714756

Abstract

Iron-deficiency anaemia will develop in half the males and nearly all females after partial gastrectomy, and in addition to causing the anaemia the sideropenia may cause any general symptoms such as lassitude, failure to maintain weight, or dumping symptoms.

The variable response to treatment is due to the fact that ferrous iron is not adequately released from coated tablets taken after meals and rapidly emptied from the gastric remnant. Treatment with chelated iron is more reliable, and one tablet taken on lying down each night is adequate in the treatment of mild anaemia and for its prevention in women during the reproductive life.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BAIRD I. M., WILSON G. M. The pathogenesis of anaemia after partial gastrectomy. II. Iron absorption after partial gastrectomy. Q J Med. 1959 Jan;28(109):35–41. [PubMed] [Google Scholar]
  2. BARNES R. D. The low incidence of gastro-intestinal symptoms encountered in the clinical use of a chelated oral iron compound. Practitioner. 1960 Jun;184:789–792. [PubMed] [Google Scholar]
  3. BLAKE J., RECHNITZER P. A. The haematological and nutritional effects of gastric operations. Q J Med. 1953 Oct;22(88):419–437. [PubMed] [Google Scholar]
  4. BOTHWELL T. H., MALLETT B., OLIVER R., SMITH M. D. Inability to assess absorption of iron from plasma radioiron curves. Br J Haematol. 1955 Oct;1(4):352–357. doi: 10.1111/j.1365-2141.1955.tb05520.x. [DOI] [PubMed] [Google Scholar]
  5. BOTHWELL T. H., PIRZIO-BIROLI G., FINCH C. A. Iron absorption. I. Factors influencing absorption. J Lab Clin Med. 1958 Jan;51(1):24–36. [PubMed] [Google Scholar]
  6. BRUMFITT W. Primary iron-deficiency anaemia in young men. Q J Med. 1960 Jan;29:1–18. [PubMed] [Google Scholar]
  7. BURGE H. W. Vagotomy in the treatment of peptic ulceration. Postgrad Med J. 1960 Jan;36:2–13. doi: 10.1136/pgmj.36.411.2. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. CHODOS R. B., ROSS J. F., APT L., POLLYCOVE M., HALKETT J. A. The absorption of radioiron labeled foods and iron salts in normal and iron-deficient subjects and in idiopathic hemochromatosis. J Clin Invest. 1957 Feb;36(2):314–326. doi: 10.1172/JCI103427. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. CHOUDHURY M. R., WILLIAMS J. Iron absorption and gastric operations. Clin Sci. 1959 Nov;18:527–532. [PubMed] [Google Scholar]
  10. COX E. V., MEYNELL M. J., GADDIE R., COOKE W. T. Interrelation of vitamin B12 and iron. Lancet. 1959 Dec 5;2(7110):998–1001. doi: 10.1016/s0140-6736(59)91468-0. [DOI] [PubMed] [Google Scholar]
  11. DUTHIE H. L. Partial gastrectomy for peptic ulcer: six years after. Scott Med J. 1959 Nov;4:523–526. [PubMed] [Google Scholar]
  12. FEINSTEIN A. R., BETHARD W. F., McCARTHY J. D. A new method, using radioiron, for determining the iron-binding capacity of human serum. J Lab Clin Med. 1953 Dec;42(6):907–914. [PubMed] [Google Scholar]
  13. GOLDECK H., GADERMANN E. Zum Eisenstoffwechsel nach Magenresektion. Arztl Wochensch. 1954 Jan 8;9(2):39–40. [PubMed] [Google Scholar]
  14. Gibson Q. H., Harrison D. C. An artificial standard for use in the estimation of haemoglobin. Biochem J. 1945;39(5):490–497. doi: 10.1042/bj0390490. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. HEINRICH G. Die Wirkung der Folsäure auf die Eisenresorptionsstörung nach Magenresektion. Arztl Wochensch. 1954 Jun 25;9(26):609–611. [PubMed] [Google Scholar]
  16. JACOBI H., PFLEGER K., RUMMEL W. Komplexbildner und aktiver Eisentransport durch die Darmwand. Naunyn Schmiedebergs Arch Exp Pathol Pharmakol. 1956;229(2):198–206. [PubMed] [Google Scholar]
  17. JENNISON R. F. Trial of an iron chelate in the treatment of anaemia of pregnancy. Practitioner. 1958 Dec;181(1086):731–735. [PubMed] [Google Scholar]
  18. Jones N. C. Measurement of Red-cell Loss from Gastro-intestinal Tract, using Radioactive Chromium. Br Med J. 1958 Mar 1;1(5069):493–496. doi: 10.1136/bmj.1.5069.493. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. MOORE C. V. The importance of nutritional factors in the pathogenesis of iron-deficiency anemia. Am J Clin Nutr. 1955 Jan-Feb;3(1):3–10. doi: 10.1093/ajcn/3.1.3. [DOI] [PubMed] [Google Scholar]
  20. MURRAY D. H., Jr, NAJARIAN J. S., BUSTER C. D., SCOTT K. G., HARPER H. A., McCORKLE H. J. Absorption of radioactive iron after gastrectomy. Surg Forum. 1957;8:211–214. [PubMed] [Google Scholar]
  21. OTT W., JASINSKI B. Nachuntersuchungen zum Thema Dumpingsyndrom und larvierter Eisenmangel. Gastroenterologia. 1954 Jul;82(1):14–19. [PubMed] [Google Scholar]
  22. OWREN P. A. The pathogenesis and treatment of iron deficiency anemia after partial gastrectomy. Acta Chir Scand. 1952 Dec 10;104(2-3):206–214. [PubMed] [Google Scholar]
  23. PATTARIN L. Le variazioni del quadro sieroproteico in pazienti sottoposti a sezione per forme morbose del tratto gastro-duodenale. Arch Ital Mal Appar Dig. 1958;24(3):187–197. [PubMed] [Google Scholar]
  24. SMITH M. D., MALLETT B. Iron absorption before and after partial gastrectomy. Clin Sci. 1957 Feb;16(1):23–34. [PubMed] [Google Scholar]
  25. STEVENS A. R., Jr, PIRZIO-BIROLI G., HARKINS H. N., NYHUS L. M., FINCH C. A. Iron metabolism in patients after partial gastrectomy. Ann Surg. 1959 Apr;149(4):534–538. doi: 10.1097/00000658-195904000-00013. [DOI] [PMC free article] [PubMed] [Google Scholar]
  26. THOMAS J. E. Mechanics and regulation of gastric emptying. Physiol Rev. 1957 Oct;37(4):453–474. doi: 10.1152/physrev.1957.37.4.453. [DOI] [PubMed] [Google Scholar]
  27. ZINGG W., GREEN P. T., THOMAS E. J. Studies on iron absorption following partial gastrectomy. Gastroenterology. 1959 Jun;36(6):806–811. [PubMed] [Google Scholar]

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